High-speed ultrahigh-resolution OCT of bruch's membrane in membranoproliferative glomerulonephritis type 2

Mehreen Adhi, Sarah P. Read, Jonathan J. Liu, James G. Fujimoto, Jay S. Duker

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Membranoproliferative glomerulonephritis (MPGN) type 2 is characterized by electron-dense deposits in the glomerular basement membrane and drusen-like deposits in Bruch's membrane. Over time, atrophic changes in the retina and retinal pigment epithelium occur, which can progress to choroidal neovascularization (CNV). This report describes a patient with MPGN type 2 who developed progressive loss of vision secondary to CNV. High-speed ultrahigh-resolution optical coherence tomography (UHR-OCT) showed an irregular Bruch's membrane that measured 10 μm beneath the foveal center. High-speed UHR-OCT can potentially be used to analyze Bruch's membrane in secondary ocular manifestations of diseases such as MPGN type 2 and primary retinal diseases such as age-related macular degeneration.

Original languageEnglish (US)
Pages (from-to)614-617
Number of pages4
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume45
Issue number6
DOIs
StatePublished - Nov 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

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