Highly Flexible Silicone Coated Neural Array for Intracochlear Electrical Stimulation

P. Bhatti, J. Van Beek-King, A. Sharpe, J. Crawford, S. Tridandapani, Brian McKinnon, D. Blake

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We present an effective method for tailoring the flexibility of a commercial thin-film polymer electrode array for intracochlear electrical stimulation. Using a pneumatically driven dispensing system, an average 232±64 μm (mean ± SD) thickness layer of silicone adhesive coating was applied to stiffen the underside of polyimide multisite arrays. Additional silicone was applied to the tip to protect neural tissue during insertion and along the array to improve surgical handling. Each array supported 20 platinum sites (180 μm dia., 250 μm pitch), spanning nearly 28 mm in length and 400 m in width. We report an average intracochlear stimulating current threshold of 170±93 μA to evoke an auditory brainstem response in 7 acutely deafened felines. A total of 10 arrays were each inserted through a round window approach into the cochlea's basal turn of eight felines with one delamination occurring upon insertion (preliminary results of the in vivo data presented at the 48th Annual Meeting American Neurotology Society, Orlando, FL, April 2013, and reported in Van Beek-King 2014). Using microcomputed tomography imaging (50 μm resolution), distances ranging from 100 to 565 m from the cochlea's central modiolus were measured. Our method combines the utility of readily available commercial devices with a straightforward postprocessing step on the order of 24 hours.

Original languageEnglish (US)
Article number109702
JournalBioMed Research International
Volume2015
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Cochlea
Felidae
Silicones
Electric Stimulation
Neurotology
X-Ray Microtomography
Brain Stem Auditory Evoked Potentials
Platinum
Delamination
Polyimides
Adhesives
Tomography
Polymers
Electrodes
Tissue
Imaging techniques
Thin films
Equipment and Supplies
Coatings

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Bhatti, P., Van Beek-King, J., Sharpe, A., Crawford, J., Tridandapani, S., McKinnon, B., & Blake, D. (2015). Highly Flexible Silicone Coated Neural Array for Intracochlear Electrical Stimulation. BioMed Research International, 2015, [109702]. https://doi.org/10.1155/2015/109702

Highly Flexible Silicone Coated Neural Array for Intracochlear Electrical Stimulation. / Bhatti, P.; Van Beek-King, J.; Sharpe, A.; Crawford, J.; Tridandapani, S.; McKinnon, Brian; Blake, D.

In: BioMed Research International, Vol. 2015, 109702, 01.01.2015.

Research output: Contribution to journalArticle

Bhatti, P, Van Beek-King, J, Sharpe, A, Crawford, J, Tridandapani, S, McKinnon, B & Blake, D 2015, 'Highly Flexible Silicone Coated Neural Array for Intracochlear Electrical Stimulation', BioMed Research International, vol. 2015, 109702. https://doi.org/10.1155/2015/109702
Bhatti, P. ; Van Beek-King, J. ; Sharpe, A. ; Crawford, J. ; Tridandapani, S. ; McKinnon, Brian ; Blake, D. / Highly Flexible Silicone Coated Neural Array for Intracochlear Electrical Stimulation. In: BioMed Research International. 2015 ; Vol. 2015.
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