Hindbrain herniation

A review of embryological theories

R. Shane Tubbs, Mohammadali Mohajel Shoja, Mohammad R. Ardalan, Ghaffar Shokouhi, Marios Loukas

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Herniation of the hindbrain outside of the setting of intracranial hypertension, trauma, and brain tumors is an uncommon phenomenon with estimated incidence of less than 1%. In the late 1890's, Hans Chiari, a German pathologist, classified hindbrain herniation into three forms. This classification was then extended to include six types. We reviewed the current literature for the proposed embryological theories as well as the potential genetic mutations/syndromes associated with the hindbrain herniation or Chiari malformation. The review is illustrated by a unique cadaver with Chiari type I malformation (i.e. herniation of the cerebellar tonsils through the foramen magnum). Finally, it seems that no single theory could explain all forms of the Chiari malformation, and that this malformation might be a heterogeneous entity.

Original languageEnglish (US)
Pages (from-to)37-46
Number of pages10
JournalItalian Journal of Anatomy and Embryology
Volume113
Issue number1
StatePublished - Jan 1 2008
Externally publishedYes

Fingerprint

Rhombencephalon
Arnold-Chiari Malformation
Foramen Magnum
Encephalocele
Intracranial Hypertension
Palatine Tonsil
Cadaver
Brain Neoplasms
Mutation
Incidence
Wounds and Injuries

Keywords

  • Chiari I malformation
  • Craniocervical junction
  • Embryology
  • Genetic
  • Hindbrain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tubbs, R. S., Mohajel Shoja, M., Ardalan, M. R., Shokouhi, G., & Loukas, M. (2008). Hindbrain herniation: A review of embryological theories. Italian Journal of Anatomy and Embryology, 113(1), 37-46.

Hindbrain herniation : A review of embryological theories. / Tubbs, R. Shane; Mohajel Shoja, Mohammadali; Ardalan, Mohammad R.; Shokouhi, Ghaffar; Loukas, Marios.

In: Italian Journal of Anatomy and Embryology, Vol. 113, No. 1, 01.01.2008, p. 37-46.

Research output: Contribution to journalArticle

Tubbs, RS, Mohajel Shoja, M, Ardalan, MR, Shokouhi, G & Loukas, M 2008, 'Hindbrain herniation: A review of embryological theories', Italian Journal of Anatomy and Embryology, vol. 113, no. 1, pp. 37-46.
Tubbs RS, Mohajel Shoja M, Ardalan MR, Shokouhi G, Loukas M. Hindbrain herniation: A review of embryological theories. Italian Journal of Anatomy and Embryology. 2008 Jan 1;113(1):37-46.
Tubbs, R. Shane ; Mohajel Shoja, Mohammadali ; Ardalan, Mohammad R. ; Shokouhi, Ghaffar ; Loukas, Marios. / Hindbrain herniation : A review of embryological theories. In: Italian Journal of Anatomy and Embryology. 2008 ; Vol. 113, No. 1. pp. 37-46.
@article{274c64a9012d433dbaebab8b8cf080cf,
title = "Hindbrain herniation: A review of embryological theories",
abstract = "Herniation of the hindbrain outside of the setting of intracranial hypertension, trauma, and brain tumors is an uncommon phenomenon with estimated incidence of less than 1{\%}. In the late 1890's, Hans Chiari, a German pathologist, classified hindbrain herniation into three forms. This classification was then extended to include six types. We reviewed the current literature for the proposed embryological theories as well as the potential genetic mutations/syndromes associated with the hindbrain herniation or Chiari malformation. The review is illustrated by a unique cadaver with Chiari type I malformation (i.e. herniation of the cerebellar tonsils through the foramen magnum). Finally, it seems that no single theory could explain all forms of the Chiari malformation, and that this malformation might be a heterogeneous entity.",
keywords = "Chiari I malformation, Craniocervical junction, Embryology, Genetic, Hindbrain",
author = "Tubbs, {R. Shane} and {Mohajel Shoja}, Mohammadali and Ardalan, {Mohammad R.} and Ghaffar Shokouhi and Marios Loukas",
year = "2008",
month = "1",
day = "1",
language = "English (US)",
volume = "113",
pages = "37--46",
journal = "Italian Journal of Anatomy and Embryology",
issn = "1122-6714",
publisher = "Firenze University Press",
number = "1",

}

TY - JOUR

T1 - Hindbrain herniation

T2 - A review of embryological theories

AU - Tubbs, R. Shane

AU - Mohajel Shoja, Mohammadali

AU - Ardalan, Mohammad R.

AU - Shokouhi, Ghaffar

AU - Loukas, Marios

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Herniation of the hindbrain outside of the setting of intracranial hypertension, trauma, and brain tumors is an uncommon phenomenon with estimated incidence of less than 1%. In the late 1890's, Hans Chiari, a German pathologist, classified hindbrain herniation into three forms. This classification was then extended to include six types. We reviewed the current literature for the proposed embryological theories as well as the potential genetic mutations/syndromes associated with the hindbrain herniation or Chiari malformation. The review is illustrated by a unique cadaver with Chiari type I malformation (i.e. herniation of the cerebellar tonsils through the foramen magnum). Finally, it seems that no single theory could explain all forms of the Chiari malformation, and that this malformation might be a heterogeneous entity.

AB - Herniation of the hindbrain outside of the setting of intracranial hypertension, trauma, and brain tumors is an uncommon phenomenon with estimated incidence of less than 1%. In the late 1890's, Hans Chiari, a German pathologist, classified hindbrain herniation into three forms. This classification was then extended to include six types. We reviewed the current literature for the proposed embryological theories as well as the potential genetic mutations/syndromes associated with the hindbrain herniation or Chiari malformation. The review is illustrated by a unique cadaver with Chiari type I malformation (i.e. herniation of the cerebellar tonsils through the foramen magnum). Finally, it seems that no single theory could explain all forms of the Chiari malformation, and that this malformation might be a heterogeneous entity.

KW - Chiari I malformation

KW - Craniocervical junction

KW - Embryology

KW - Genetic

KW - Hindbrain

UR - http://www.scopus.com/inward/record.url?scp=42549137865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42549137865&partnerID=8YFLogxK

M3 - Article

VL - 113

SP - 37

EP - 46

JO - Italian Journal of Anatomy and Embryology

JF - Italian Journal of Anatomy and Embryology

SN - 1122-6714

IS - 1

ER -