TY - JOUR
T1 - Histamine-releasing factors and inhibitors
T2 - Historical perspectives and possible implications in human illness
AU - Grant, J. Andrew
AU - Alam, Rafeul
AU - Lett-Brown, Michael A.
N1 - Funding Information:
program and grant from Fisons Corporation.
Funding Information:
From the Allergy and Immunology Division, Department of Internal Medicine, The University of Texas Medical Branch at Galveston, Galveston, Texas. Supported by National Institutes of Health Grant AI-22940 and a John Sealy Endowment Grant. Presented in part as a postgraduate lecture at the Annual Meeting of the American Academy of Allergy and Immunology, San Antonio, Texas, Feb. 24-March 1, 1989. Reprint requests: J. Andrew Grant, MD, University of Texas Med-ical Branch, Route G-62, Galveston, TX 77550. *Recipient of a Burroughs-Wellcome New Investigator Merit Award and a National Institutes of Health Young Investigator Award Al-27864. l/2/29770
PY - 1991/11
Y1 - 1991/11
N2 - The initiation of allergic reactions with the bridging of surface-bound IgE antibodies on mast cells and basophils by allergens is well recognized. However, it is clear that other factors most likely play a role in regulating these cells. A number of cytokines have been identified that modulate the secretory response of mast cells and basophils. Among the well-characterized cytokines, interleukin-3 and connective tissue-activating peptide III (or its degradation product, neutrophil-activating peptide 2) can increase the secretory response, whereas interleukin-8 specifically inhibits the response to cytokines. Additional factors are currently under investigation. Preliminary studies suggest an important role for these histamine-releasing factors in atopic disorders, as well as in other conditions in which an IgE-dependent mechanism is not demonstrable. Furthermore, these cytokines may modulate the response of basophils and mast cells in physiologic conditions, such as tissue repair and host defense.
AB - The initiation of allergic reactions with the bridging of surface-bound IgE antibodies on mast cells and basophils by allergens is well recognized. However, it is clear that other factors most likely play a role in regulating these cells. A number of cytokines have been identified that modulate the secretory response of mast cells and basophils. Among the well-characterized cytokines, interleukin-3 and connective tissue-activating peptide III (or its degradation product, neutrophil-activating peptide 2) can increase the secretory response, whereas interleukin-8 specifically inhibits the response to cytokines. Additional factors are currently under investigation. Preliminary studies suggest an important role for these histamine-releasing factors in atopic disorders, as well as in other conditions in which an IgE-dependent mechanism is not demonstrable. Furthermore, these cytokines may modulate the response of basophils and mast cells in physiologic conditions, such as tissue repair and host defense.
KW - Histamine-releasing factor
KW - basophils
KW - histamine
KW - hypersensitivity
KW - interleukins
UR - http://www.scopus.com/inward/record.url?scp=0026331605&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026331605&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(91)90170-S
DO - 10.1016/0091-6749(91)90170-S
M3 - Article
C2 - 1720148
AN - SCOPUS:0026331605
SN - 0091-6749
VL - 88
SP - 683
EP - 693
JO - The Journal of Allergy and Clinical Immunology
JF - The Journal of Allergy and Clinical Immunology
IS - 5
ER -