Histamine-releasing factors and inhibitory factors

J. Andrew Grant; Rafeul Alam; Michael A. Lett-Brown

doi:10.1159/000235346

Histamine-releasing factors and inhibitory factors

J. Andrew Grant, Rafeul Alam, Michael A. Lett-Brown

Internal Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.

Original language	English (US)
Pages (from-to)	141-143
Number of pages	3
Journal	International Archives of Allergy and Immunology
Volume	94
Issue number	1-4
DOIs	https://doi.org/10.1159/000235346
State	Published - 1991

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "Histamine-releasing factors and inhibitory factors",

abstract = "Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.",

author = "Grant, {J. Andrew} and Rafeul Alam and Lett-Brown, {Michael A.}",

year = "1991",

doi = "10.1159/000235346",

language = "English (US)",

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pages = "141--143",

journal = "International Archives of Allergy and Immunology",

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AU - Grant, J. Andrew

AU - Alam, Rafeul

AU - Lett-Brown, Michael A.

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AB - Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.

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JF - International Archives of Allergy and Immunology

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Histamine-releasing factors and inhibitory factors

Abstract

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