Histamine-releasing factors and inhibitory factors

J. A. Grant, R. Alam, M. A. Lett-Brown

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalInternational Archives of Allergy and Applied Immunology
Volume94
Issue number1-4
StatePublished - 1991

    Fingerprint

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Grant, J. A., Alam, R., & Lett-Brown, M. A. (1991). Histamine-releasing factors and inhibitory factors. International Archives of Allergy and Applied Immunology, 94(1-4), 141-143.