Histamine-releasing factors and inhibitory factors

J. A. Grant, R. Alam, M. A. Lett-Brown

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalInternational Archives of Allergy and Applied Immunology
Volume94
Issue number1-4
StatePublished - 1991

Fingerprint

Histamine Release
Interleukin-3
Interleukin-8
Histamine
Blood Cells
Molecular Weight
Cytokines
translationally-controlled 1 tumor protein
connective tissue-activating peptide

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Grant, J. A., Alam, R., & Lett-Brown, M. A. (1991). Histamine-releasing factors and inhibitory factors. International Archives of Allergy and Applied Immunology, 94(1-4), 141-143.

Histamine-releasing factors and inhibitory factors. / Grant, J. A.; Alam, R.; Lett-Brown, M. A.

In: International Archives of Allergy and Applied Immunology, Vol. 94, No. 1-4, 1991, p. 141-143.

Research output: Contribution to journalArticle

Grant, JA, Alam, R & Lett-Brown, MA 1991, 'Histamine-releasing factors and inhibitory factors', International Archives of Allergy and Applied Immunology, vol. 94, no. 1-4, pp. 141-143.
Grant, J. A. ; Alam, R. ; Lett-Brown, M. A. / Histamine-releasing factors and inhibitory factors. In: International Archives of Allergy and Applied Immunology. 1991 ; Vol. 94, No. 1-4. pp. 141-143.
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