Histamine-releasing factors and inhibitory factors

J. Andrew Grant, Rafeul Alam, Michael A. Lett-Brown

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalInternational Archives of Allergy and Immunology
Issue number1-4
StatePublished - 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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