Abstract
Peripheral-blood mononuclear cells (MNC) synthesize several histamine-releasing factors (HRF) spontaneously and when stimulated. Some of the characterized cytokines have histamine-releasing activity, especially connective tissue activating peptide III, neutrophil-activating peptide 2 and interleukin-3 (IL-3). At least two species of HRF remain to be characterized. MNC also secrete a histamine release-inhibitory factor (HRIF), which is a highly specific inhibitor, because it antagonizes only HRF. IL-8 resembles the low-molecular-weight species of HRIF in terms of size and specificity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 141-143 |
| Number of pages | 3 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 94 |
| Issue number | 1-4 |
| DOIs | |
| State | Published - 1991 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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