Histamine-triggered localized vasculitis in patients with seropositive rheumatoid arthritis

J. L. Jorizzo, J. C. Daniels, P. Apisarnthanarax, Emilio Gonzalez, T. Cavallo

Research output: Contribution to journalArticle

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Abstract

To gain some insight into the pathogenesis of vasculitis in rheumatoid arthritis, and to investigate its relation to circulating immunoreactants, we injected 50 μl of histamine intradermally in 4 seropositive and 4 seronegative patients with rheumatoid arthritis. Skin biopsies obtained before histamine and at 4 hours after histamine were studied by immunofluorescence microscopy, and skin biopsies 24 hours after histamine were studied by light microscopy. At 4 hours after histamine, all seropositive patients demonstrated deposits of IgM and complement components in dermal vessels; by 24 hours, various degrees of leukocytoclastic vasculitis were noted. Circulating material reactive with Raji cells, C1q, or both, was present in 3/3 seropositive patients. In contrast, none of the seronegative patients exhibited vascular deposits of immunoreactants or vasculitis. The results indicate that patients with rheumatoid arthritis who are seropositive may have circulating complexes with appropriate characteristics to induce vasculitis and that vasoactive substances may be used to trigger their local deposition in vessels.

Original languageEnglish (US)
Pages (from-to)845-851
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume9
Issue number6
DOIs
StatePublished - 1983

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Vasculitis
Histamine
Rheumatoid Arthritis
Skin
Biopsy
Fluorescence Microscopy
Immunoglobulin M
Blood Vessels
Microscopy
Light

ASJC Scopus subject areas

  • Dermatology

Cite this

Histamine-triggered localized vasculitis in patients with seropositive rheumatoid arthritis. / Jorizzo, J. L.; Daniels, J. C.; Apisarnthanarax, P.; Gonzalez, Emilio; Cavallo, T.

In: Journal of the American Academy of Dermatology, Vol. 9, No. 6, 1983, p. 845-851.

Research output: Contribution to journalArticle

Jorizzo, J. L. ; Daniels, J. C. ; Apisarnthanarax, P. ; Gonzalez, Emilio ; Cavallo, T. / Histamine-triggered localized vasculitis in patients with seropositive rheumatoid arthritis. In: Journal of the American Academy of Dermatology. 1983 ; Vol. 9, No. 6. pp. 845-851.
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