Histocompatibility antigen patterns in haemophilic patients with factor VIII antibodies

Ashraf M. Aly, Louis M. Aledort, Tsung D. Lee, Leon W. Hoyer

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Abstract

Summary A number of studies suggest that there is a genetic basis for the formation by some haemophilia A patients of antibodies that inactivate factor VIII. In our study, human leucocyte antigen (HLA)‐A, B. C, DR and DQ typing was carried out for 44 haemophilia A patients, including 16 who had developed an antibody to factor VIII. In contrast to previous reports, we found no association between HLA‐DR antigens and haemophilia A per se or the formation of a factor VIII inhibitor. However, there was an absence of HLA‐Cw5 in the 16 haemophilic patients who had formed an antibody to factor VIII. This finding, consistent with a previous report, identified a statistically significant difference in HLA‐Cw5 frequency when the inhibitor patient group was compared to multi‐transfused haemophilic patients who had no inhibitor (11/28).

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalBritish Journal of Haematology
Volume76
Issue number2
DOIs
StatePublished - Oct 1990
Externally publishedYes

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ASJC Scopus subject areas

  • Hematology

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