Histocompatibility antigen patterns in haemophilic patients with factor VIII antibodies.

Ashraf Aly, L. M. Aledort, T. D. Lee, L. W. Hoyer

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A number of studies suggest that there is a genetic basis for the formation by some haemophilia A patients of antibodies that inactivate factor VIII. In our study, human leucocyte antigen (HLA)-A, B, C, DR and DQ typing was carried out for 44 haemophilia A patients, including 16 who had developed an antibody to factor VIII. In contrast to previous reports, we found no association between HLA-DR antigens and haemophilia A per se or the formation of a factor VIII inhibitor. However, there was an absence of HLA-Cw5 in the 16 haemophilic patients who had formed an antibody to factor VIII. This finding, consistent with a previous report, identified a statistically significant difference in HLA-Cw5 frequency when the inhibitor patient group was compared to multi-transfused haemophilic patients who had no inhibitor (11/28).

Original languageEnglish (US)
Pages (from-to)238-241
Number of pages4
JournalBritish Journal of Haematology
Volume76
Issue number2
StatePublished - Oct 1990
Externally publishedYes

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Histocompatibility Antigens
Factor VIII
HLA Antigens
Hemophilia A
Antibodies
Antigens

ASJC Scopus subject areas

  • Hematology

Cite this

Histocompatibility antigen patterns in haemophilic patients with factor VIII antibodies. / Aly, Ashraf; Aledort, L. M.; Lee, T. D.; Hoyer, L. W.

In: British Journal of Haematology, Vol. 76, No. 2, 10.1990, p. 238-241.

Research output: Contribution to journalArticle

Aly, Ashraf ; Aledort, L. M. ; Lee, T. D. ; Hoyer, L. W. / Histocompatibility antigen patterns in haemophilic patients with factor VIII antibodies. In: British Journal of Haematology. 1990 ; Vol. 76, No. 2. pp. 238-241.
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