Histologic identification of brown adipose and peripheral nerve involvement in human atherosclerotic vessels

Elizabeth Salisbury, John Hipp, Elizabeth A. Olmsted-Davis, Alan R. Davis, Michael H. Heggeness, Francis H. Gannon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The disease mechanisms and histology of plaque development associated with atherosclerosis remain incredibly complex and not entirely understood. Recent investigations have emphasized the importance of inflammation in atherosclerosis. Several studies have also indicated heterotopic or extraskeletal bone formation in atherosclerotic vessels. The mechanisms behind heterotopic ossification appear to have similarities to those underlying atherosclerosis, with inflammation being a key inductive component to heterotopic ossification. Therefore, in the present study, we evaluated the histology associated with pathologies of atherosclerosis and heterotopic ossification in 271 coronary vessel tissue samples. We examined the prevalence and features of the inflammatory response as well as new vessel and bone formation. Inflammation and neovascularization were observed both in the adventitia and within the atherosclerotic lesions of the vessels themselves. Intriguingly, neural changes, including collections of inflammatory cells and expression of neuroinflammatory factors, were detected in the adventitial nerves of the vessels. Mature lamellar bone was found in 18 coronary vessels (7%), often with hematopoietic elements and active bone remodeling. Brown adipocytes, which pattern heterotopic bone formation, were present within the atherosclerotic lesions (28%, or 75/271). As expected, there was a strong correlation between the presence of cholesterol and plaque formation (P

Original languageEnglish (US)
Pages (from-to)2213-2222
Number of pages10
JournalHuman Pathology
Volume43
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

Fingerprint

Heterotopic Ossification
Peripheral Nerves
Atherosclerosis
Osteogenesis
Adventitia
Inflammation
Coronary Vessels
Histology
Brown Adipocytes
Bone Remodeling
Cholesterol
Pathology
Bone and Bones

Keywords

  • Atherosclerosis
  • Bone
  • Bone morphogenetic protein
  • Brown adipocyte
  • Heterotopic ossification
  • Nerve

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Histologic identification of brown adipose and peripheral nerve involvement in human atherosclerotic vessels. / Salisbury, Elizabeth; Hipp, John; Olmsted-Davis, Elizabeth A.; Davis, Alan R.; Heggeness, Michael H.; Gannon, Francis H.

In: Human Pathology, Vol. 43, No. 12, 12.2012, p. 2213-2222.

Research output: Contribution to journalArticle

Salisbury, Elizabeth ; Hipp, John ; Olmsted-Davis, Elizabeth A. ; Davis, Alan R. ; Heggeness, Michael H. ; Gannon, Francis H. / Histologic identification of brown adipose and peripheral nerve involvement in human atherosclerotic vessels. In: Human Pathology. 2012 ; Vol. 43, No. 12. pp. 2213-2222.
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