Histologic response of porcine collagen-coated and uncoated polypropylene grafts in a rabbit vagina model

R. Keith Huffaker, Tristi W. Muir, Arundhati Rao, Shannon S. Baumann, Thomas J. Kuehl, Lisa M. Pierce

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Objective: The purpose of this study was to determine whether the host tissue response in the rabbit vagina differs for 2 synthetic graft materials that are used in pelvic reconstructive surgery. Study Design: One strip of porcine collagen-coated or uncoated polypropylene mesh was implanted adjacent to a sham operative site into the posterior vagina of 10 New Zealand white rabbits and harvested 12 weeks later. Rabbits were assigned randomly to group 1 (coated; n = 5), group 2 (uncoated; n = 5), or group 3 (unoperated; n = 4). Full-thickness sagittal sections of posterior vaginal wall and rectum were scored for inflammation, neovascularization, and fibroblastic proliferation. Results: Erosion of grafts did not occur in any animal. Coated and uncoated meshes induced a mild inflammatory response with minimal fibrosis and good host tissue incorporation within the grafts. Few apoptotic and proliferating cells were seen for both graft types. Conclusion: Both coated and uncoated polypropylene meshes elicit a mild foreign body reaction and minimal fibrotic response without evidence of vaginal epithelial erosion.

Original languageEnglish (US)
Pages (from-to)582.e1-582.e7
JournalAmerican journal of obstetrics and gynecology
Issue number5
StatePublished - May 2008
Externally publishedYes


  • Histologic finding
  • pelvic organ prolapse
  • polypropylene mesh
  • rabbit model
  • synthetic graft
  • vagina

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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