HIV-1 Genetic Diversity in Recently Diagnosed Infections in Moscow: Predominance of A FSU , Frequent Branching in Clusters, and Circulation of the Iberian Subtype G Variant

Eduard Karamov, Khoren Epremyan, Andrei Siniavin, Yury Zhernov, María Teresa Cuevas, Elena Delgado, Mónica Sánchez-Martínez, Cristina Carrera, Galina Kornilaeva, Ali Turgiev, Joan Bacqué, Lucía Pérez-Álvarez, Michael M. Thomson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

HIV-1 protease-reverse transcriptase sequences from 62 HIV-1-infected individuals recently diagnosed in Moscow were analyzed. Subtype A former Soviet Union (FSU) (A FSU ) variant was the predominant clade (62.9%), followed by subtype B (22.6%), unique recombinants (6.5%), subtype G (6.5%), and CRF01-AE (1.6%). A FSU predominated among people who inject drugs (88.9%) and heterosexually acquired infections (77.8%), while subtype B was the most prevalent genetic form among men who have sex with men (44%), although A FSU was also frequent in this population (36%). Forty-eight (77.4%) viruses branched within intrasubtype clusters, three of which, of subtype B, had a majority of viruses collected outside of FSU. The four subtype G viruses identified in this study belonged to the Portuguese-Spanish (Iberian) variant and, together with three from databases, formed a Russian cluster closely related to viruses from Denmark. This is the first report of the circulation of the Iberian subtype G variant in Russia.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalAIDS Research and Human Retroviruses
Volume34
Issue number7
DOIs
StatePublished - Jul 2018
Externally publishedYes

Keywords

  • clusters
  • HIV-1
  • recombinant forms
  • Russia
  • subtypes

ASJC Scopus subject areas

  • Immunology
  • Infectious Diseases
  • Virology

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