TY - JOUR
T1 - HIV-1 Genetic Diversity in Recently Diagnosed Infections in Moscow
T2 - Predominance of A FSU , Frequent Branching in Clusters, and Circulation of the Iberian Subtype G Variant
AU - Karamov, Eduard
AU - Epremyan, Khoren
AU - Siniavin, Andrei
AU - Zhernov, Yury
AU - Cuevas, María Teresa
AU - Delgado, Elena
AU - Sánchez-Martínez, Mónica
AU - Carrera, Cristina
AU - Kornilaeva, Galina
AU - Turgiev, Ali
AU - Bacqué, Joan
AU - Pérez-Álvarez, Lucía
AU - Thomson, Michael M.
N1 - Publisher Copyright:
© Copyright 2018, Mary Ann Liebert, Inc.
PY - 2018/7
Y1 - 2018/7
N2 - HIV-1 protease-reverse transcriptase sequences from 62 HIV-1-infected individuals recently diagnosed in Moscow were analyzed. Subtype A former Soviet Union (FSU) (A FSU ) variant was the predominant clade (62.9%), followed by subtype B (22.6%), unique recombinants (6.5%), subtype G (6.5%), and CRF01-AE (1.6%). A FSU predominated among people who inject drugs (88.9%) and heterosexually acquired infections (77.8%), while subtype B was the most prevalent genetic form among men who have sex with men (44%), although A FSU was also frequent in this population (36%). Forty-eight (77.4%) viruses branched within intrasubtype clusters, three of which, of subtype B, had a majority of viruses collected outside of FSU. The four subtype G viruses identified in this study belonged to the Portuguese-Spanish (Iberian) variant and, together with three from databases, formed a Russian cluster closely related to viruses from Denmark. This is the first report of the circulation of the Iberian subtype G variant in Russia.
AB - HIV-1 protease-reverse transcriptase sequences from 62 HIV-1-infected individuals recently diagnosed in Moscow were analyzed. Subtype A former Soviet Union (FSU) (A FSU ) variant was the predominant clade (62.9%), followed by subtype B (22.6%), unique recombinants (6.5%), subtype G (6.5%), and CRF01-AE (1.6%). A FSU predominated among people who inject drugs (88.9%) and heterosexually acquired infections (77.8%), while subtype B was the most prevalent genetic form among men who have sex with men (44%), although A FSU was also frequent in this population (36%). Forty-eight (77.4%) viruses branched within intrasubtype clusters, three of which, of subtype B, had a majority of viruses collected outside of FSU. The four subtype G viruses identified in this study belonged to the Portuguese-Spanish (Iberian) variant and, together with three from databases, formed a Russian cluster closely related to viruses from Denmark. This is the first report of the circulation of the Iberian subtype G variant in Russia.
KW - clusters
KW - HIV-1
KW - recombinant forms
KW - Russia
KW - subtypes
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U2 - 10.1089/aid.2018.0055
DO - 10.1089/aid.2018.0055
M3 - Article
C2 - 29587492
AN - SCOPUS:85049402462
SN - 0889-2229
VL - 34
SP - 629
EP - 634
JO - AIDS Research and Human Retroviruses
JF - AIDS Research and Human Retroviruses
IS - 7
ER -