HIV-1 gp120Bal down-Regulates Phosphorylated NMDA Receptor Subunit 1 in Cortical Neurons via Activation of Glutamate and Chemokine Receptors

Wenjuan Ru, Shao-Jun Tang

    Research output: Contribution to journalArticle

    7 Scopus citations

    Abstract

    HIV-1 envelope glycoprotein gp120 (gp120) is a major virulence protein implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Although gp120 has been suggested to cause synaptic and neuronal injuries by disrupting NMDA receptor (NMDAR) function, the underlying mechanism is unclear. Here, we show that gp120Bal down-regulates the phosphorylation of the NMDAR subunit1 NR1 (at Ser896 and Ser897), which is essential for NMDAR function. This effect of gp120Bal is blocked by specific antagonists of both NMDA and AMPA receptors, indicating a critical role of synaptic activation. Furthermore, AMD3100 and maraviroc, antagonists of CCR5 and CXCR4 chemokine receptors, respectively, inhibit the effect of gp120Bal on NR1, suggesting that CXCR4 and CCR5 activation are involved. These findings may provide mechanistic insights into the synaptopathogenesis caused by HIV-1 infection.

    Original languageEnglish (US)
    Pages (from-to)182-191
    Number of pages10
    JournalJournal of NeuroImmune Pharmacology
    Volume11
    Issue number1
    DOIs
    StatePublished - Mar 1 2016

    Keywords

    • gp120
    • HIV-1
    • NMDA receptor
    • Phosphorylation
    • Synapse

    ASJC Scopus subject areas

    • Pharmacology
    • Immunology and Allergy
    • Immunology
    • Neuroscience (miscellaneous)

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