HIV-1-Infected Antiretroviral-Treated Patients with Prolonged Partial Viral Suppression: Clinical, Virologic, and Immunologic Course

Allan R. Tenorio, Kimberly Y. Smith, Daniel R. Kuritzkes, Beverly E. Sha, Betty Donoval, Russell Young, Cheryl Jennings, James Bremer, Susan Shott, Alan Landay, Harold A. Kessler

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The long-term feasibility of a drug conservation strategy that allows low-level viral replication is unknown. We performed a retrospective study of treated HIV-infected patients with stable detectable viral replication (<10,000 copies/mL [low-level viremia]) and compared their clinical, virologic and immunologic courses with those of treated patients with undetectable viremia and viremia (≥10,000 copies/mL [high-level viremia]). Viral reverse transcriptase and protease genotype and HIV-specific CD4 T-cell responses were determined using patient-derived samples. Clinical and immunologic benefits were maintained in patients with partial virologic suppression (≤10,000 copies/mL). Although low-level viral replication under drug pressure led to the accumulation of resistance mutations in most subjects' viruses, most subjects retained susceptibility to drugs in ≥2 classes of antiretroviral medications. HIV-specific CD4+ T-cell immunity was detected in most subjects with low-level and undetectable viremia and may have a role in controlling viremia in the setting of partial suppression.

Original languageEnglish (US)
Pages (from-to)491-496
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume34
Issue number5
DOIs
StatePublished - Dec 15 2003
Externally publishedYes

Keywords

  • Drug resistance
  • HIV-specific immunity
  • Partial virologic suppression

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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