HIV-1 replication cycle

Monique R. Ferguson, Daniel R. Rojo, Jana J. Von Lindern, William A. O'Brien

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The HIV-1 is a formidable pathogen with establishment of a persistent infection based on the ability to integrate the proviral genome into chronically infected cells, and by the rapid evolution made possible by a high mutation rate and frequent recombination during the viral replication. HIV-1 has a variety of novel genes that facilitate viral persistence and regulation of HIV replication, but this virus also usurps cellular machinery for HIV replication, particularly during gene expression and virion assembly and budding. Recent success with antiretroviral therapy may be limited by the emergence HIV drug resistance and by toxicities and other requirements for successful long-term therapy. Further investigation of HIV-1 replication may allow identification of novel targets of antiretroviral therapy that may allow continued virus suppression in patients of failing current regiments, particularly drugs that target HIV-1 entry and HIV-1 integration.

Original languageEnglish (US)
Pages (from-to)611-635
Number of pages25
JournalClinics in Laboratory Medicine
Volume22
Issue number3
DOIs
StatePublished - Sep 1 2002

    Fingerprint

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ferguson, M. R., Rojo, D. R., Von Lindern, J. J., & O'Brien, W. A. (2002). HIV-1 replication cycle. Clinics in Laboratory Medicine, 22(3), 611-635. https://doi.org/10.1016/S0272-2712(02)00015-X