HIV-1 subtype diversity in the pathogenesis of neuroHIV

Monray E. Williams; Lindokuhle Thela; Charles Wood; Robert H. Paul; Vurayai Ruhanya; Petrus J.W. Naude; Eliseo Eugenin

doi:10.1038/s41583-025-01015-z

HIV-1 subtype diversity in the pathogenesis of neuroHIV

Monray E. Williams
, Lindokuhle Thela
, Charles Wood
, Robert H. Paul
, Vurayai Ruhanya
, Petrus J.W. Naude
, Eliseo Eugenin

Neurobiology

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Despite advances in HIV-1 treatment, half of all people living with HIV-1 experience HIV-associated neurocognitive disorders (HAND). Most of our understanding of HAND neuropathogenesis comes from studies of individuals with HIV-1 subtype B, which is responsible for a small proportion of global HIV-1 infections. By contrast, HIV-1 subtype C, which predominates in sub-Saharan Africa, affects many more people but remains poorly characterized, limiting our understanding of HAND at a global level.

Original language	English (US)
Pages (from-to)	81-82
Number of pages	2
Journal	Nature Reviews Neuroscience
Volume	27
Issue number	2
DOIs	https://doi.org/10.1038/s41583-025-01015-z
State	Published - Feb 2026

ASJC Scopus subject areas

General Neuroscience

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10.1038/s41583-025-01015-z

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title = "HIV-1 subtype diversity in the pathogenesis of neuroHIV",

abstract = "Despite advances in HIV-1 treatment, half of all people living with HIV-1 experience HIV-associated neurocognitive disorders (HAND). Most of our understanding of HAND neuropathogenesis comes from studies of individuals with HIV-1 subtype B, which is responsible for a small proportion of global HIV-1 infections. By contrast, HIV-1 subtype C, which predominates in sub-Saharan Africa, affects many more people but remains poorly characterized, limiting our understanding of HAND at a global level.",

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AU - Williams, Monray E.

AU - Thela, Lindokuhle

AU - Wood, Charles

AU - Paul, Robert H.

AU - Ruhanya, Vurayai

AU - Naude, Petrus J.W.

AU - Eugenin, Eliseo

N1 - Publisher Copyright: © Springer Nature Limited 2026.

PY - 2026/2

Y1 - 2026/2

N2 - Despite advances in HIV-1 treatment, half of all people living with HIV-1 experience HIV-associated neurocognitive disorders (HAND). Most of our understanding of HAND neuropathogenesis comes from studies of individuals with HIV-1 subtype B, which is responsible for a small proportion of global HIV-1 infections. By contrast, HIV-1 subtype C, which predominates in sub-Saharan Africa, affects many more people but remains poorly characterized, limiting our understanding of HAND at a global level.

AB - Despite advances in HIV-1 treatment, half of all people living with HIV-1 experience HIV-associated neurocognitive disorders (HAND). Most of our understanding of HAND neuropathogenesis comes from studies of individuals with HIV-1 subtype B, which is responsible for a small proportion of global HIV-1 infections. By contrast, HIV-1 subtype C, which predominates in sub-Saharan Africa, affects many more people but remains poorly characterized, limiting our understanding of HAND at a global level.

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UR - https://www.scopus.com/pages/publications/105026404727#tab=citedBy

U2 - 10.1038/s41583-025-01015-z

DO - 10.1038/s41583-025-01015-z

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SN - 1471-003X

VL - 27

SP - 81

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JO - Nature Reviews Neuroscience

JF - Nature Reviews Neuroscience

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HIV-1 subtype diversity in the pathogenesis of neuroHIV

Abstract

ASJC Scopus subject areas

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