HIV-Associated Cardiovascular Disease

Role of Connexin 43

Lisa Prevedel, Camilla Morocho, Michael V.L. Bennett, Eliseo Eugenin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Chronic HIV infection due to effective antiretroviral treatment has resulted in a broad range of clinical complications, including accelerated heart disease. Individuals with HIV infection have a 1.5 to 2 times higher incidence of cardiovascular diseases than their uninfected counterparts; however, the underlying mechanisms are poorly understood. To explore the link between HIV infection and cardiovascular diseases, we used postmortem human heart tissues obtained from HIV-infected and control uninfected individuals to examine connexin 43 (Cx43) expression and distribution and HIV-associated inflammation. Here, we demonstrate that Cx43 is dysregulated in the hearts of HIV-infected individuals. In all HIV heart samples analyzed, there were areas where Cx43 was overexpressed and found along the lateral membrane of the cardiomyocyte and in the intercalated disks. Areas of HIV tissue with anomalous Cx43 expression and localization also showed calcium overload, sarcofilamental atrophy, and accumulation of collagen. All these changes were independent of viral replication, CD4 counts, inflammation, and type of antiretroviral treatment. Overall, we propose that HIV infection increases Cx43 expression in heart, resulting in tissue damage that likely contributes to the high rates of cardiovascular disease in HIV-infected individuals.

Original languageEnglish (US)
Pages (from-to)1960-1970
Number of pages11
JournalAmerican Journal of Pathology
Volume187
Issue number9
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Fingerprint

Connexin 43
Cardiovascular Diseases
HIV
HIV Infections
Inflammation
CD4 Lymphocyte Count
Cardiac Myocytes
Atrophy
Heart Diseases
Collagen
Calcium
Membranes
Incidence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

HIV-Associated Cardiovascular Disease : Role of Connexin 43. / Prevedel, Lisa; Morocho, Camilla; Bennett, Michael V.L.; Eugenin, Eliseo.

In: American Journal of Pathology, Vol. 187, No. 9, 01.09.2017, p. 1960-1970.

Research output: Contribution to journalArticle

Prevedel, Lisa ; Morocho, Camilla ; Bennett, Michael V.L. ; Eugenin, Eliseo. / HIV-Associated Cardiovascular Disease : Role of Connexin 43. In: American Journal of Pathology. 2017 ; Vol. 187, No. 9. pp. 1960-1970.
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