HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter

John R. Keltner, Christine Fennema-Notestine, Florin Vaida, Dongzhe Wang, Donald R. Franklin, Robert H. Dworkin, Chelsea Sanders, J. Allen McCutchan, Sarah L. Archibald, David J. Miller, George Kesidis, Clint Cushman, Sung Min Kim, Ian Abramson, Michael J. Taylor, Rebecca J. Theilmann, Michelle D. Julaton, Randy J. Notestine, Stephanie Corkran, Mariana Cherner & 13 others Nichole A. Duarte, Terry Alexander, Jessica Robinson-Papp, Benjamin Gelman, David M. Simpson, Ann C. Collier, Christina M. Marra, Susan Morgello, Greg Brown, Igor Grant, J. Hampton Atkinson, Terry L. Jernigan, Ronald J. Ellis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Despite modern antiretroviral therapy, HIVassociated sensory neuropathy affects over 50% of HIV patients. The clinical expression of HIV neuropathy is highly variable: many individuals report few symptoms, but about half report distal neuropathic pain (DNP), making it one of the most prevalent, disabling, and treatment-resistant complications of HIV disease. The presence and intensity of pain is not fully explained by the degree of peripheral nerve damage, making it unclear why some patients do, and others do not, report pain. To better understand central nervous system contributions to HIV DNP, we performed a cross-sectional analysis of structural magnetic resonance imaging volumes in 241 HIV-infected participants from an observational multi-site cohort study at five US sites (CNS HIV Anti-Retroviral Treatment Effects Research Study, CHAR TER). The association between DNP and the structural imaging outcomes was investigated using both linear and nonlinear (Gaussian Kernel support vector) multivariable regression, controlling for key demographic and clinical variables. Severity of DNP symptoms was correlated with smaller total cerebral cortical gray matter volume (r = -0.24; p =0.004). Understanding the mechanisms for this association between smaller total cortical volumes and DNP may provide insight into HIV DNP chronicity and treatment-resistance.

Original languageEnglish (US)
Pages (from-to)209-218
Number of pages10
JournalJournal of NeuroVirology
Volume20
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Neuralgia
HIV
Pain
Therapeutics
Gray Matter
Peripheral Nerves
Cohort Studies
Central Nervous System
Cross-Sectional Studies
Magnetic Resonance Imaging
Demography
Research

Keywords

  • Cortical volume
  • HIV distal neuropathic pain
  • Structural MRI

ASJC Scopus subject areas

  • Virology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Neurology
  • Medicine(all)

Cite this

Keltner, J. R., Fennema-Notestine, C., Vaida, F., Wang, D., Franklin, D. R., Dworkin, R. H., ... Ellis, R. J. (2014). HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter. Journal of NeuroVirology, 20(3), 209-218. https://doi.org/10.1007/s13365-014-0236-8

HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter. / Keltner, John R.; Fennema-Notestine, Christine; Vaida, Florin; Wang, Dongzhe; Franklin, Donald R.; Dworkin, Robert H.; Sanders, Chelsea; McCutchan, J. Allen; Archibald, Sarah L.; Miller, David J.; Kesidis, George; Cushman, Clint; Kim, Sung Min; Abramson, Ian; Taylor, Michael J.; Theilmann, Rebecca J.; Julaton, Michelle D.; Notestine, Randy J.; Corkran, Stephanie; Cherner, Mariana; Duarte, Nichole A.; Alexander, Terry; Robinson-Papp, Jessica; Gelman, Benjamin; Simpson, David M.; Collier, Ann C.; Marra, Christina M.; Morgello, Susan; Brown, Greg; Grant, Igor; Atkinson, J. Hampton; Jernigan, Terry L.; Ellis, Ronald J.

In: Journal of NeuroVirology, Vol. 20, No. 3, 2014, p. 209-218.

Research output: Contribution to journalArticle

Keltner, JR, Fennema-Notestine, C, Vaida, F, Wang, D, Franklin, DR, Dworkin, RH, Sanders, C, McCutchan, JA, Archibald, SL, Miller, DJ, Kesidis, G, Cushman, C, Kim, SM, Abramson, I, Taylor, MJ, Theilmann, RJ, Julaton, MD, Notestine, RJ, Corkran, S, Cherner, M, Duarte, NA, Alexander, T, Robinson-Papp, J, Gelman, B, Simpson, DM, Collier, AC, Marra, CM, Morgello, S, Brown, G, Grant, I, Atkinson, JH, Jernigan, TL & Ellis, RJ 2014, 'HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter', Journal of NeuroVirology, vol. 20, no. 3, pp. 209-218. https://doi.org/10.1007/s13365-014-0236-8
Keltner, John R. ; Fennema-Notestine, Christine ; Vaida, Florin ; Wang, Dongzhe ; Franklin, Donald R. ; Dworkin, Robert H. ; Sanders, Chelsea ; McCutchan, J. Allen ; Archibald, Sarah L. ; Miller, David J. ; Kesidis, George ; Cushman, Clint ; Kim, Sung Min ; Abramson, Ian ; Taylor, Michael J. ; Theilmann, Rebecca J. ; Julaton, Michelle D. ; Notestine, Randy J. ; Corkran, Stephanie ; Cherner, Mariana ; Duarte, Nichole A. ; Alexander, Terry ; Robinson-Papp, Jessica ; Gelman, Benjamin ; Simpson, David M. ; Collier, Ann C. ; Marra, Christina M. ; Morgello, Susan ; Brown, Greg ; Grant, Igor ; Atkinson, J. Hampton ; Jernigan, Terry L. ; Ellis, Ronald J. / HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter. In: Journal of NeuroVirology. 2014 ; Vol. 20, No. 3. pp. 209-218.
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AU - Dworkin, Robert H.

AU - Sanders, Chelsea

AU - McCutchan, J. Allen

AU - Archibald, Sarah L.

AU - Miller, David J.

AU - Kesidis, George

AU - Cushman, Clint

AU - Kim, Sung Min

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AU - Taylor, Michael J.

AU - Theilmann, Rebecca J.

AU - Julaton, Michelle D.

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AU - Jernigan, Terry L.

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