HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response

Haitao Hu, Fengliang Liu, Jerome Kim, Silvia Ratto-Kim

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

ABSTRACT: HIV causes infection and progressive depletion of human CD4 T cells. Emerging data have shown that antigen-specific CD4 T-cell subsets manifest differential susceptibility to HIV, potentially leading to pathogen-specific immune failure and opportunistic infections. This concept was recently explored in context of vectors utilized in HIV vaccine trials, and the data suggest that adenovirus type 5(Ad5)-specific CD4 T cells elicited by Ad5-HIV vaccine may be particularly susceptible to HIV, potentially rendering Ad5 vaccine recipients susceptible to HIV acquisition. We here examined recent data regarding the HIV susceptibility of antigen-specific CD4 T cells induced during infection or HIV vaccination and discussed its potential impact on HIV acquisition risk posed by HIV vaccination.

Original languageEnglish (US)
Pages (from-to)709-717
Number of pages9
JournalExpert review of vaccines
Volume15
Issue number6
DOIs
StatePublished - Jun 2 2016

Keywords

  • CD4 T cells
  • HIV susceptibility
  • HIV vaccine
  • antigen specificity
  • pathogenesis

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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