HIV tat and neurotoxicity

J. E. King, Eliseo Eugenin, C. M. Buckner, J. W. Berman

Research output: Contribution to journalShort survey

145 Scopus citations

Abstract

HIV tat is the transactivator of HIV-1, supporting efficient viral replication by stabilizing the transcription of viral genes. Tat can be released from HIV-infected cells and alter several functions in uninfected cells. In the brain, tat induces neuronal dysfunction/toxicity, even though neurons cannot be directly infected with HIV, resulting in CNS pathology, such as the dementia and encephalitis associated with NeuroAIDS. This review discusses the most recent data addressing tat-induced neurotoxicity and integrates these new findings in the context of NeuroAIDS.

Original languageEnglish (US)
Pages (from-to)1347-1357
Number of pages11
JournalMicrobes and Infection
Volume8
Issue number5
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

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Keywords

  • Apoptosis
  • CCL2
  • Glutamate
  • Inflammation
  • NeuroAIDS

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

King, J. E., Eugenin, E., Buckner, C. M., & Berman, J. W. (2006). HIV tat and neurotoxicity. Microbes and Infection, 8(5), 1347-1357. https://doi.org/10.1016/j.micinf.2005.11.014