HIV type 1 and cytomegalovirus coinfection in the female genital tract

Nell S. Lurain, Emmanuel S. Robert, Jiahong Xu, Margaret Camarca, Alan Landay, Andrea A. Kovacs, Patricia S. Reichelderfer

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


The relationship between human immunodeficiency virus (HIV) type 1 and human cytomegalovirus (CMV) was studied in blood, saliva, and cervicovaginal lavage (CVL) specimens from 33 HIV-1-infected women. An association between HIV-1 RNA and CMV DNA was found in the CVL specimens, which also were tested for cytokine levels. Women with detectable CMV DNA in CVL specimens were more likely to have higher interleukin (IL)-1β and IL-8 levels than were women with undetectable CMV DNA in CVL specimens. More than 1 strain of CMV was detected in specimens from 2 patients. These results suggest mechanisms by which CMV coinfection could affect HIV-1 disease progression.

Original languageEnglish (US)
Pages (from-to)619-623
Number of pages5
JournalJournal of Infectious Diseases
Issue number3
StatePublished - Aug 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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