HLA-DQB1 and cervical cancer in Venezuelan women

Dat D. Dao, Carlos H. Sierra-Torres, Sonia C. Robazetti, Miriam Naranjo De Gomez, Rolf König, Carolina Lema, L. James Lester, William W. Au, Stephen K. Tyring

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cervical cancer represents a major health problem in Venezuela as well as in other Latin American countries. High-risk human papillomavirus (HR-HPV) infection is known as the major risk factor of cervical cancer. However, whether or not a HR-HPV-infected woman progresses to cervical cancer may depend on the immune system effectors induced by viral antigens presented by her specific human leukocyte antigens (HLA) alleles. The role of the HLA system in presenting peptides to antigen-specific T-cells may be critical for genetic susceptibility and genetic resistance to cervical carcinoma. We aimed to investigate the relationship between HLA-DQB1, HPV infection, and cervical cancer in Venezuelan women. Blood samples and cervical swabs were obtained from 36 patients and 79 healthy controls; additional cervical biopsies were obtained from all the patients. HPV DNA was detected by PCR and HLA-DQB1 genotyping was performed using a PCR-SSP protocol. A positive association with cervical cancer was observed for HLA-DQB1*0201-0202 and*0402 alleles, however after Bonferroni correction only HLA-DQB1*0402 remained statistically significant (P value = 0.004, RR = 5.067). This is the first report of HLA-DQB1 alleles associated with cervical carcinoma in Venezuelan women. Larger studies are needed to assess whether these HLA-DQB1*0201-0202 and*0402 alleles have a direct effect on disease susceptibility.

Original languageEnglish (US)
Pages (from-to)349-354
Number of pages6
JournalGynecologic Oncology
Volume96
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

HLA Antigens
Uterine Cervical Neoplasms
Alleles
Carcinoma
Polymerase Chain Reaction
Venezuela
Papillomavirus Infections
Viral Antigens
Disease Susceptibility
Genetic Predisposition to Disease
Immune System
T-Lymphocytes
Biopsy
Antigens
Peptides
DNA
Health
Infection

Keywords

  • Cervical cancer
  • Genetic susceptibility
  • HLA-DQB1
  • Venezuelan women

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Dao, D. D., Sierra-Torres, C. H., Robazetti, S. C., De Gomez, M. N., König, R., Lema, C., ... Tyring, S. K. (2005). HLA-DQB1 and cervical cancer in Venezuelan women. Gynecologic Oncology, 96(2), 349-354. https://doi.org/10.1016/j.ygyno.2004.10.002

HLA-DQB1 and cervical cancer in Venezuelan women. / Dao, Dat D.; Sierra-Torres, Carlos H.; Robazetti, Sonia C.; De Gomez, Miriam Naranjo; König, Rolf; Lema, Carolina; Lester, L. James; Au, William W.; Tyring, Stephen K.

In: Gynecologic Oncology, Vol. 96, No. 2, 02.2005, p. 349-354.

Research output: Contribution to journalArticle

Dao, DD, Sierra-Torres, CH, Robazetti, SC, De Gomez, MN, König, R, Lema, C, Lester, LJ, Au, WW & Tyring, SK 2005, 'HLA-DQB1 and cervical cancer in Venezuelan women', Gynecologic Oncology, vol. 96, no. 2, pp. 349-354. https://doi.org/10.1016/j.ygyno.2004.10.002
Dao DD, Sierra-Torres CH, Robazetti SC, De Gomez MN, König R, Lema C et al. HLA-DQB1 and cervical cancer in Venezuelan women. Gynecologic Oncology. 2005 Feb;96(2):349-354. https://doi.org/10.1016/j.ygyno.2004.10.002
Dao, Dat D. ; Sierra-Torres, Carlos H. ; Robazetti, Sonia C. ; De Gomez, Miriam Naranjo ; König, Rolf ; Lema, Carolina ; Lester, L. James ; Au, William W. ; Tyring, Stephen K. / HLA-DQB1 and cervical cancer in Venezuelan women. In: Gynecologic Oncology. 2005 ; Vol. 96, No. 2. pp. 349-354.
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