TY - JOUR
T1 - Hormonal status affects the reactivity of the cerebral vasculature
AU - Belfort, Michael A.
AU - Saade, George R.
AU - Snabes, Michael
AU - Dunn, Randall
AU - Moise, Kenneth J.
AU - Cruz, Arcadia
AU - Young, Ronald
N1 - Funding Information:
From the Divisions of Maternal-Fetal Medicine” and Reproductive Endocrinology” Department of Obstetrics and Gynecology, and the Department of Anesthesiology,,” Baylor College of Medicine. Supported by a Grant-In-Aid from the American Heart Association and by a grant from Mead Johnson Pharmaceuticals. Presented in Part at the Forty-first Annual Meeting of the Society for Gynecologic investigation, Chicago, Illinois, Ma&k 22-26, 1994. Received for publication July 19, 1994; revised September 28, 1994; accepted October 3, 1994. Reprint requests: Michael A. Belfort, MD, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology One Baylor Plaza, Houston, TX 77030. Copyright 0 1995 by Mosby-Year Book, Inc. 0002-9378/95 $3.00 f 0 6/l/60985
PY - 1995
Y1 - 1995
N2 - OBJECTIVE: We compared the blood velocity and vascular resistance in the central retinal and ophthalmic arteries in healthy nonpregnant, pregnant, and postmenopausal women (before and after estrogen replacement therapy). STUDY DESIGN: Color flow Doppler ultrasoography was used to determine systolic, diastolic, and mean velocity, as well as the resistance index in the central retinal and ophthalmic arteries in 10 nonpregnant women, 10 third-trimester pregnant women, and 10 hypoestrogenic postmenopausal women. The postmenopausal patients were again studied 2 months after starting daily oral therapy with 2 mg of micronized 17β-estradiol. RESULTS: Pregnant women had a significantly (p < 0.05) higher diastolic blood velocity (4.2 ± 0.8 cm/sec) and a lower resistance idnex (0.56 ± 0.05) in the central retinal artery, when compared with nonpregnant women (diastolic velocity 2.6 ± 0.8 cm/sec, resistance index 0.68 = 0.1), and hypoestrogenic postmenopausal women (diastolic velocity 2.6 ± 0.9 cm/sec, resistance index 0.73 ± 0.08). Significant differences were not seen in the opthalmic artery. In the postmenopausal patients estradiol therapy was associated with an increase in diastolic velocity (2.6 ± 0.9 cm/sec vs 4.1 ± 1.6 cm/sec) and a decrease in the resistance index (0.73 ± 0.08 vs 0.66 ± 0.1) in the central retinal artery but not in the ophthalmic artery. CONCLUSIONS: The blood velocity and vascular resistance in the cerebral microcirculation appear to change according to the phases of a woman's reproductive life. This may be related, in part, to estrogen level, because estradiol vasodilates small-diameter cerebral vessels in hypoestrogenic postmenopausal women.
AB - OBJECTIVE: We compared the blood velocity and vascular resistance in the central retinal and ophthalmic arteries in healthy nonpregnant, pregnant, and postmenopausal women (before and after estrogen replacement therapy). STUDY DESIGN: Color flow Doppler ultrasoography was used to determine systolic, diastolic, and mean velocity, as well as the resistance index in the central retinal and ophthalmic arteries in 10 nonpregnant women, 10 third-trimester pregnant women, and 10 hypoestrogenic postmenopausal women. The postmenopausal patients were again studied 2 months after starting daily oral therapy with 2 mg of micronized 17β-estradiol. RESULTS: Pregnant women had a significantly (p < 0.05) higher diastolic blood velocity (4.2 ± 0.8 cm/sec) and a lower resistance idnex (0.56 ± 0.05) in the central retinal artery, when compared with nonpregnant women (diastolic velocity 2.6 ± 0.8 cm/sec, resistance index 0.68 = 0.1), and hypoestrogenic postmenopausal women (diastolic velocity 2.6 ± 0.9 cm/sec, resistance index 0.73 ± 0.08). Significant differences were not seen in the opthalmic artery. In the postmenopausal patients estradiol therapy was associated with an increase in diastolic velocity (2.6 ± 0.9 cm/sec vs 4.1 ± 1.6 cm/sec) and a decrease in the resistance index (0.73 ± 0.08 vs 0.66 ± 0.1) in the central retinal artery but not in the ophthalmic artery. CONCLUSIONS: The blood velocity and vascular resistance in the cerebral microcirculation appear to change according to the phases of a woman's reproductive life. This may be related, in part, to estrogen level, because estradiol vasodilates small-diameter cerebral vessels in hypoestrogenic postmenopausal women.
KW - Doppler
KW - Estradiol
KW - central retinal artery
KW - cerebral blood flow
KW - menopause
KW - pregnancy
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U2 - 10.1016/0002-9378(95)91492-7
DO - 10.1016/0002-9378(95)91492-7
M3 - Article
C2 - 7726269
AN - SCOPUS:0028913357
SN - 0002-9378
VL - 172
SP - 1273
EP - 1278
JO - American journal of obstetrics and gynecology
JF - American journal of obstetrics and gynecology
IS - 4
ER -