Hormonal status affects the reactivity of the cerebral vasculature

M. A. Belfort, George Saade, M. Snabes, R. Dunn, K. J. Moise, A. Cruz, R. Young

Research output: Contribution to journalArticle

115 Citations (Scopus)

Abstract

Objective: We compared the blood velocity and vascular resistance in the central retinal and ophthalmic arteries in healthy nonpregnant, pregnant, and postmenopausal women (before and after estrogen replacement therapy). Study design: Color flow Doppler ultrasonography was used to determine systolic, diastolic, and mean velocity, as well as the resistance index in the central retinal and ophthalmic arteries in 10 nonpregnant women, 10 third-trimester pregnant women, and 10 hypoestrogenic postmenopausal women. The postmenopausal patients were again studied 2 months after starting daily oral therapy with 2 mg of micronized 17β-estradiol. Results: Pregnant women had a significantly (p < 0.05) higher diastolic blood velocity (4.2 ± 0.8 cm/sec) and a lower resistance index (0.56 ± 0.05) in the central retinal artery, when compared with nonpregnant women (diastolic velocity 2.8 ± 0.8 cm/sec, resistance index 0.68 ± 0.1), and hypoestrogenic postmenopausal women (diastolic velocity 2.6 ± 0.9 cm/sec, resistance index 0.73 ± 0.08). Significant differences were not seen in the ophthalmic artery. In the postmenopausal patients estradiol therapy was associated with an increase in diastolic velocity (2.6 ± 0.8 cm/sec vs 4.1 ± 1.6 cm/sec) and a decrease in the resistance index (0.73 ± 0.08 vs 0.66 ± 0.1) in the central retinal artery but not in the ophthalmic artery. Conclusions: The blood velocity and vascular resistance in the cerebral microcirculation appear to change according to the phases of a woman's reproductive life. This may be related, In part, to estrogen levels, because estradiol vasodilates small-diameter cerebral vessels in hypoestrogenic postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume172
Issue number4 I
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Ophthalmic Artery
Retinal Artery
Pregnant Women
Estradiol
Vascular Resistance
Doppler Color Ultrasonography
Estrogen Replacement Therapy
Third Pregnancy Trimester
Microcirculation
Estrogens
Therapeutics

Keywords

  • Central retinal artery
  • Cerebral blood flow
  • Doppler
  • Estradiol
  • Menopause
  • Pregnancy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Hormonal status affects the reactivity of the cerebral vasculature. / Belfort, M. A.; Saade, George; Snabes, M.; Dunn, R.; Moise, K. J.; Cruz, A.; Young, R.

In: American Journal of Obstetrics and Gynecology, Vol. 172, No. 4 I, 1995, p. 1273-1278.

Research output: Contribution to journalArticle

Belfort, M. A. ; Saade, George ; Snabes, M. ; Dunn, R. ; Moise, K. J. ; Cruz, A. ; Young, R. / Hormonal status affects the reactivity of the cerebral vasculature. In: American Journal of Obstetrics and Gynecology. 1995 ; Vol. 172, No. 4 I. pp. 1273-1278.
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abstract = "Objective: We compared the blood velocity and vascular resistance in the central retinal and ophthalmic arteries in healthy nonpregnant, pregnant, and postmenopausal women (before and after estrogen replacement therapy). Study design: Color flow Doppler ultrasonography was used to determine systolic, diastolic, and mean velocity, as well as the resistance index in the central retinal and ophthalmic arteries in 10 nonpregnant women, 10 third-trimester pregnant women, and 10 hypoestrogenic postmenopausal women. The postmenopausal patients were again studied 2 months after starting daily oral therapy with 2 mg of micronized 17β-estradiol. Results: Pregnant women had a significantly (p < 0.05) higher diastolic blood velocity (4.2 ± 0.8 cm/sec) and a lower resistance index (0.56 ± 0.05) in the central retinal artery, when compared with nonpregnant women (diastolic velocity 2.8 ± 0.8 cm/sec, resistance index 0.68 ± 0.1), and hypoestrogenic postmenopausal women (diastolic velocity 2.6 ± 0.9 cm/sec, resistance index 0.73 ± 0.08). Significant differences were not seen in the ophthalmic artery. In the postmenopausal patients estradiol therapy was associated with an increase in diastolic velocity (2.6 ± 0.8 cm/sec vs 4.1 ± 1.6 cm/sec) and a decrease in the resistance index (0.73 ± 0.08 vs 0.66 ± 0.1) in the central retinal artery but not in the ophthalmic artery. Conclusions: The blood velocity and vascular resistance in the cerebral microcirculation appear to change according to the phases of a woman's reproductive life. This may be related, In part, to estrogen levels, because estradiol vasodilates small-diameter cerebral vessels in hypoestrogenic postmenopausal women.",
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T1 - Hormonal status affects the reactivity of the cerebral vasculature

AU - Belfort, M. A.

AU - Saade, George

AU - Snabes, M.

AU - Dunn, R.

AU - Moise, K. J.

AU - Cruz, A.

AU - Young, R.

PY - 1995

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N2 - Objective: We compared the blood velocity and vascular resistance in the central retinal and ophthalmic arteries in healthy nonpregnant, pregnant, and postmenopausal women (before and after estrogen replacement therapy). Study design: Color flow Doppler ultrasonography was used to determine systolic, diastolic, and mean velocity, as well as the resistance index in the central retinal and ophthalmic arteries in 10 nonpregnant women, 10 third-trimester pregnant women, and 10 hypoestrogenic postmenopausal women. The postmenopausal patients were again studied 2 months after starting daily oral therapy with 2 mg of micronized 17β-estradiol. Results: Pregnant women had a significantly (p < 0.05) higher diastolic blood velocity (4.2 ± 0.8 cm/sec) and a lower resistance index (0.56 ± 0.05) in the central retinal artery, when compared with nonpregnant women (diastolic velocity 2.8 ± 0.8 cm/sec, resistance index 0.68 ± 0.1), and hypoestrogenic postmenopausal women (diastolic velocity 2.6 ± 0.9 cm/sec, resistance index 0.73 ± 0.08). Significant differences were not seen in the ophthalmic artery. In the postmenopausal patients estradiol therapy was associated with an increase in diastolic velocity (2.6 ± 0.8 cm/sec vs 4.1 ± 1.6 cm/sec) and a decrease in the resistance index (0.73 ± 0.08 vs 0.66 ± 0.1) in the central retinal artery but not in the ophthalmic artery. Conclusions: The blood velocity and vascular resistance in the cerebral microcirculation appear to change according to the phases of a woman's reproductive life. This may be related, In part, to estrogen levels, because estradiol vasodilates small-diameter cerebral vessels in hypoestrogenic postmenopausal women.

AB - Objective: We compared the blood velocity and vascular resistance in the central retinal and ophthalmic arteries in healthy nonpregnant, pregnant, and postmenopausal women (before and after estrogen replacement therapy). Study design: Color flow Doppler ultrasonography was used to determine systolic, diastolic, and mean velocity, as well as the resistance index in the central retinal and ophthalmic arteries in 10 nonpregnant women, 10 third-trimester pregnant women, and 10 hypoestrogenic postmenopausal women. The postmenopausal patients were again studied 2 months after starting daily oral therapy with 2 mg of micronized 17β-estradiol. Results: Pregnant women had a significantly (p < 0.05) higher diastolic blood velocity (4.2 ± 0.8 cm/sec) and a lower resistance index (0.56 ± 0.05) in the central retinal artery, when compared with nonpregnant women (diastolic velocity 2.8 ± 0.8 cm/sec, resistance index 0.68 ± 0.1), and hypoestrogenic postmenopausal women (diastolic velocity 2.6 ± 0.9 cm/sec, resistance index 0.73 ± 0.08). Significant differences were not seen in the ophthalmic artery. In the postmenopausal patients estradiol therapy was associated with an increase in diastolic velocity (2.6 ± 0.8 cm/sec vs 4.1 ± 1.6 cm/sec) and a decrease in the resistance index (0.73 ± 0.08 vs 0.66 ± 0.1) in the central retinal artery but not in the ophthalmic artery. Conclusions: The blood velocity and vascular resistance in the cerebral microcirculation appear to change according to the phases of a woman's reproductive life. This may be related, In part, to estrogen levels, because estradiol vasodilates small-diameter cerebral vessels in hypoestrogenic postmenopausal women.

KW - Central retinal artery

KW - Cerebral blood flow

KW - Doppler

KW - Estradiol

KW - Menopause

KW - Pregnancy

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