Hormone treatment and muscle anabolism during aging: Androgens

Edgar Dillon, William J. Durham, Randall Urban, Melinda Sheffield-Moore

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Aging is associated with a gradual decline in circulating testosterone concentrations and decreased musculature in men. While testosterone administration is often considered when symptoms of hypogonadism are presented, the long-term effects of androgen use on muscle physiology are not yet fully understood. The definition of hypogonadism in men remains obscure but is generally indicated by total testosterone concentrations less than a threshold value of 300-500 ng/dL. Androgen replacement therapy is generally safe in men and women with low endogenous testosterone concentrations. The development of selective androgen receptor modulators (SARMs) may provide additional options in treatment of hypogonadism while lowering the potential of side effects often associated with long-term androgen use. Androgen administration, either alone or in combination with other treatments, can be successful in improving muscle mass by increasing protein anabolism and reducing protein catabolism in men and women. Further research is necessary to optimize the anabolic and anticatabolic properties of androgens for treatment and prevention of muscle loss in men and women.

Original languageEnglish (US)
Pages (from-to)697-700
Number of pages4
JournalClinical Nutrition
Volume29
Issue number6
DOIs
StatePublished - Dec 2010

Fingerprint

Androgens
Hormones
Hypogonadism
Testosterone
Muscles
Therapeutics
Androgen Receptors
Proteins
Research

Keywords

  • Aging
  • Men
  • Skeletal muscle
  • Testosterone
  • Women

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Hormone treatment and muscle anabolism during aging : Androgens. / Dillon, Edgar; Durham, William J.; Urban, Randall; Sheffield-Moore, Melinda.

In: Clinical Nutrition, Vol. 29, No. 6, 12.2010, p. 697-700.

Research output: Contribution to journalArticle

Dillon, Edgar ; Durham, William J. ; Urban, Randall ; Sheffield-Moore, Melinda. / Hormone treatment and muscle anabolism during aging : Androgens. In: Clinical Nutrition. 2010 ; Vol. 29, No. 6. pp. 697-700.
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