Host defense antibacterial effector cells influenced by Massive Burns

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Infections in severely burned patients frequently occur as opportunistic infections. Opportunistic invading microbes are recognized by the host's immune systems both to elicit immediate defense and to generate long-lasting adaptive immunity. The innate immune system is the first line of host defense against microbial invasion. Cells and tissues influenced by burn injury stimulate many cells related to the innate immune system. Burn-associated hyperinflammatory responses are induced during these host reactions. This immune perturbation leads to the subsequent development of extended immunosuppression caused by type 2 immune responses. To understand how and why host antibacterial defenses are suppressed by massive burns, this chapter discusses cell populations and their functions as involved in innate immunities influenced by severe burn injuries.

Original languageEnglish (US)
Title of host publicationTotal Burn Care
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Pages221-231.e3
ISBN (Electronic)9780323497428
ISBN (Print)9780323476614
DOIs
StatePublished - Nov 30 2017

Fingerprint

Burns
Immune System
Opportunistic Infections
Wounds and Injuries
Adaptive Immunity
Innate Immunity
Immunosuppression
Infection
Population

Keywords

  • Burn
  • Dendritic cells
  • Immunosuppression
  • Innate lymphoid cells
  • Macrophages
  • Neutrophils
  • Opportunistic infection
  • Type 2 immune responses

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Host defense antibacterial effector cells influenced by Massive Burns. / Kobayashi, Makiko; Toliver-Kinsky, Tracy; Suzuki, Fujio.

Total Burn Care: Fifth Edition. Elsevier Inc., 2017. p. 221-231.e3.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kobayashi, Makiko ; Toliver-Kinsky, Tracy ; Suzuki, Fujio. / Host defense antibacterial effector cells influenced by Massive Burns. Total Burn Care: Fifth Edition. Elsevier Inc., 2017. pp. 221-231.e3
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