Host immune responses to Aeromonas virulence factors

Cristi L. Galindo, Jian Sha, Amin A. Fadl, Lakshmi L. Pillai, Ashok Chopra

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Aeomonas species are emerging human pathogens, which produce an array of virulence factors and cause diseases ranging from gastroenteritis to systemic infections. These bacteria can be found in food and water and grow well and produce toxins at refrigeration temperatures, which greatly increase the risk of food poisoning. A detailed understanding of host responses to Aeromonas virulence factors is paramount to developing better treatment strategies. One of the important virulence factors of Aeromonas is the cytotoxic enterotoxin, Act, which induces potent inflammatory responses in host cells and is lethal when injected intravenously into mice. Microarray analyses of Act-treated host cells by our laboratory revealed that Act induced host cell signaling and apoptosis of macrophages and colonic epithelial cells. We furthered showed that Act production is regulated by glucose inhibited division gene A (gidA) and an iron-regulated ferric uptake regulatory (fur) gene. In addition to Act, our laboratory recently discovered new virulence factors/mechanisms, including the plasminogen-activating enzyme enolase and a type III secretion system, which contribute to Aeromonas-associated diseases. Current knowledge concerning host responses to these and other Aeromonas virulence factors is discussed.

Original languageEnglish (US)
Pages (from-to)13-26
Number of pages14
JournalCurrent Immunology Reviews
Volume2
Issue number1
DOIs
StatePublished - Feb 2006

Fingerprint

Aeromonas
Virulence Factors
Refrigeration
Foodborne Diseases
Phosphopyruvate Hydratase
Plasminogen
Enterotoxins
Gastroenteritis
Regulator Genes
Microarray Analysis
Iron
Epithelial Cells
Macrophages
Apoptosis
Bacteria
Glucose
Food
Temperature
Water
Enzymes

Keywords

  • Aeromonas
  • Apoptosis
  • Gastroenteritis
  • Inflammation
  • Septicemia
  • Virulence factors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Host immune responses to Aeromonas virulence factors. / Galindo, Cristi L.; Sha, Jian; Fadl, Amin A.; Pillai, Lakshmi L.; Chopra, Ashok.

In: Current Immunology Reviews, Vol. 2, No. 1, 02.2006, p. 13-26.

Research output: Contribution to journalArticle

Galindo, Cristi L. ; Sha, Jian ; Fadl, Amin A. ; Pillai, Lakshmi L. ; Chopra, Ashok. / Host immune responses to Aeromonas virulence factors. In: Current Immunology Reviews. 2006 ; Vol. 2, No. 1. pp. 13-26.
@article{7fec519af1db4819990ccaad4c751e36,
title = "Host immune responses to Aeromonas virulence factors",
abstract = "Aeomonas species are emerging human pathogens, which produce an array of virulence factors and cause diseases ranging from gastroenteritis to systemic infections. These bacteria can be found in food and water and grow well and produce toxins at refrigeration temperatures, which greatly increase the risk of food poisoning. A detailed understanding of host responses to Aeromonas virulence factors is paramount to developing better treatment strategies. One of the important virulence factors of Aeromonas is the cytotoxic enterotoxin, Act, which induces potent inflammatory responses in host cells and is lethal when injected intravenously into mice. Microarray analyses of Act-treated host cells by our laboratory revealed that Act induced host cell signaling and apoptosis of macrophages and colonic epithelial cells. We furthered showed that Act production is regulated by glucose inhibited division gene A (gidA) and an iron-regulated ferric uptake regulatory (fur) gene. In addition to Act, our laboratory recently discovered new virulence factors/mechanisms, including the plasminogen-activating enzyme enolase and a type III secretion system, which contribute to Aeromonas-associated diseases. Current knowledge concerning host responses to these and other Aeromonas virulence factors is discussed.",
keywords = "Aeromonas, Apoptosis, Gastroenteritis, Inflammation, Septicemia, Virulence factors",
author = "Galindo, {Cristi L.} and Jian Sha and Fadl, {Amin A.} and Pillai, {Lakshmi L.} and Ashok Chopra",
year = "2006",
month = "2",
doi = "10.2174/157339506775471910",
language = "English (US)",
volume = "2",
pages = "13--26",
journal = "Current Immunology Reviews",
issn = "1573-3955",
publisher = "Bentham Science Publishers B.V.",
number = "1",

}

TY - JOUR

T1 - Host immune responses to Aeromonas virulence factors

AU - Galindo, Cristi L.

AU - Sha, Jian

AU - Fadl, Amin A.

AU - Pillai, Lakshmi L.

AU - Chopra, Ashok

PY - 2006/2

Y1 - 2006/2

N2 - Aeomonas species are emerging human pathogens, which produce an array of virulence factors and cause diseases ranging from gastroenteritis to systemic infections. These bacteria can be found in food and water and grow well and produce toxins at refrigeration temperatures, which greatly increase the risk of food poisoning. A detailed understanding of host responses to Aeromonas virulence factors is paramount to developing better treatment strategies. One of the important virulence factors of Aeromonas is the cytotoxic enterotoxin, Act, which induces potent inflammatory responses in host cells and is lethal when injected intravenously into mice. Microarray analyses of Act-treated host cells by our laboratory revealed that Act induced host cell signaling and apoptosis of macrophages and colonic epithelial cells. We furthered showed that Act production is regulated by glucose inhibited division gene A (gidA) and an iron-regulated ferric uptake regulatory (fur) gene. In addition to Act, our laboratory recently discovered new virulence factors/mechanisms, including the plasminogen-activating enzyme enolase and a type III secretion system, which contribute to Aeromonas-associated diseases. Current knowledge concerning host responses to these and other Aeromonas virulence factors is discussed.

AB - Aeomonas species are emerging human pathogens, which produce an array of virulence factors and cause diseases ranging from gastroenteritis to systemic infections. These bacteria can be found in food and water and grow well and produce toxins at refrigeration temperatures, which greatly increase the risk of food poisoning. A detailed understanding of host responses to Aeromonas virulence factors is paramount to developing better treatment strategies. One of the important virulence factors of Aeromonas is the cytotoxic enterotoxin, Act, which induces potent inflammatory responses in host cells and is lethal when injected intravenously into mice. Microarray analyses of Act-treated host cells by our laboratory revealed that Act induced host cell signaling and apoptosis of macrophages and colonic epithelial cells. We furthered showed that Act production is regulated by glucose inhibited division gene A (gidA) and an iron-regulated ferric uptake regulatory (fur) gene. In addition to Act, our laboratory recently discovered new virulence factors/mechanisms, including the plasminogen-activating enzyme enolase and a type III secretion system, which contribute to Aeromonas-associated diseases. Current knowledge concerning host responses to these and other Aeromonas virulence factors is discussed.

KW - Aeromonas

KW - Apoptosis

KW - Gastroenteritis

KW - Inflammation

KW - Septicemia

KW - Virulence factors

UR - http://www.scopus.com/inward/record.url?scp=32344444281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32344444281&partnerID=8YFLogxK

U2 - 10.2174/157339506775471910

DO - 10.2174/157339506775471910

M3 - Article

VL - 2

SP - 13

EP - 26

JO - Current Immunology Reviews

JF - Current Immunology Reviews

SN - 1573-3955

IS - 1

ER -