How cytokines co-occur across asthma patients: From bipartite network analysis to a molecular-based classification

Suresh K. Bhavnani, Sundar Victor, William J. Calhoun, William W. Busse, Eugene Bleecker, Mario Castro, Hyunsu Ju, Regina Pillai, Numan Oezguen, Gowtham Bellala, Allan R. Brasier

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Asthmatic patients are currently classified as either severe or non-severe based primarily on their response to glucocorticoids. However, because this classification is based on a post-hoc assessment of treatment response, it does not inform the rational staging of disease or therapy. Recent studies in other diseases suggest that a classification which includes molecular information could lead to more accurate diagnoses and prediction of treatment response. We therefore measured cytokine values in bronchoalveolar lavage (BAL) samples of the lower respiratory tract obtained from 83 asthma patients, and used bipartite network visualizations with associated quantitative measures to conduct an exploratory analysis of the co-occurrence of cytokines across patients. The analysis helped to identify three clusters of patients which had a complex but understandable interaction with three clusters of cytokines, leading to insights for a state-based classification of asthma patients. Furthermore, while the patient clusters were significantly different based on key pulmonary functions, they appeared to have no significant relationship to the current classification of asthma patients. These results suggest the need to define a molecular-based classification of asthma patients, which could improve the diagnosis and treatment of this disease.

Original languageEnglish (US)
Pages (from-to)S24-S30
JournalJournal of Biomedical Informatics
Volume44
Issue numberSUPPL. 1
DOIs
StatePublished - Dec 2011

Keywords

  • Co-occurrence of cytokines
  • Molecular-based classification of asthma patients
  • Network analysis

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics

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    Bhavnani, S. K., Victor, S., Calhoun, W. J., Busse, W. W., Bleecker, E., Castro, M., Ju, H., Pillai, R., Oezguen, N., Bellala, G., & Brasier, A. R. (2011). How cytokines co-occur across asthma patients: From bipartite network analysis to a molecular-based classification. Journal of Biomedical Informatics, 44(SUPPL. 1), S24-S30. https://doi.org/10.1016/j.jbi.2011.09.006