How does Helicobacter pylori cause mucosal damage? The inflammatory response

P. B. Ernst, S. E. Crowe, Victor Reyes

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

The role for Helicobacter pylori in the pathogenesis of disease provides the conundrum that only a subset of subjects infected with H. pylori will ever develop peptic ulcer or gastric cancer. Thus, variation in strain as well as environmental or host factors converge in the gastroduodenal milieu and control the final outcome of infection. The host immune and inflammatory response is emerging as an important element in the pathogenesis of these gastric diseases. The ideal host response provides protection to clear an infection without causing excessive amounts of inflammation that could compromise the integrity and function of host cells. This review will cover four main questions: (1) What are the mucosal immune/inflammatory responses that confer protection without damaging the host? (2) How do the gastric immune responses during infection with H. pylori differ from this ideal scenario? (3) Do these responses contribute to autoimmune-mediated damage to gastric tissue? (4) Can immunomodulation through vaccination enhance protective, nondestructive responses that prevent or treat infection or, at least, attenuate inflammation?.

Original languageEnglish (US)
JournalGastroenterology
Volume113
Issue number6 SUPPL.
StatePublished - 1997
Externally publishedYes

Fingerprint

Helicobacter pylori
Infection
Stomach
Inflammation
Stomach Diseases
Mucosal Immunity
Immunomodulation
Peptic Ulcer
Stomach Neoplasms
Vaccination

ASJC Scopus subject areas

  • Gastroenterology

Cite this

How does Helicobacter pylori cause mucosal damage? The inflammatory response. / Ernst, P. B.; Crowe, S. E.; Reyes, Victor.

In: Gastroenterology, Vol. 113, No. 6 SUPPL., 1997.

Research output: Contribution to journalArticle

@article{7fe5a9a7dae244b6b8df547b2e3d946f,
title = "How does Helicobacter pylori cause mucosal damage? The inflammatory response",
abstract = "The role for Helicobacter pylori in the pathogenesis of disease provides the conundrum that only a subset of subjects infected with H. pylori will ever develop peptic ulcer or gastric cancer. Thus, variation in strain as well as environmental or host factors converge in the gastroduodenal milieu and control the final outcome of infection. The host immune and inflammatory response is emerging as an important element in the pathogenesis of these gastric diseases. The ideal host response provides protection to clear an infection without causing excessive amounts of inflammation that could compromise the integrity and function of host cells. This review will cover four main questions: (1) What are the mucosal immune/inflammatory responses that confer protection without damaging the host? (2) How do the gastric immune responses during infection with H. pylori differ from this ideal scenario? (3) Do these responses contribute to autoimmune-mediated damage to gastric tissue? (4) Can immunomodulation through vaccination enhance protective, nondestructive responses that prevent or treat infection or, at least, attenuate inflammation?.",
author = "Ernst, {P. B.} and Crowe, {S. E.} and Victor Reyes",
year = "1997",
language = "English (US)",
volume = "113",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "6 SUPPL.",

}

TY - JOUR

T1 - How does Helicobacter pylori cause mucosal damage? The inflammatory response

AU - Ernst, P. B.

AU - Crowe, S. E.

AU - Reyes, Victor

PY - 1997

Y1 - 1997

N2 - The role for Helicobacter pylori in the pathogenesis of disease provides the conundrum that only a subset of subjects infected with H. pylori will ever develop peptic ulcer or gastric cancer. Thus, variation in strain as well as environmental or host factors converge in the gastroduodenal milieu and control the final outcome of infection. The host immune and inflammatory response is emerging as an important element in the pathogenesis of these gastric diseases. The ideal host response provides protection to clear an infection without causing excessive amounts of inflammation that could compromise the integrity and function of host cells. This review will cover four main questions: (1) What are the mucosal immune/inflammatory responses that confer protection without damaging the host? (2) How do the gastric immune responses during infection with H. pylori differ from this ideal scenario? (3) Do these responses contribute to autoimmune-mediated damage to gastric tissue? (4) Can immunomodulation through vaccination enhance protective, nondestructive responses that prevent or treat infection or, at least, attenuate inflammation?.

AB - The role for Helicobacter pylori in the pathogenesis of disease provides the conundrum that only a subset of subjects infected with H. pylori will ever develop peptic ulcer or gastric cancer. Thus, variation in strain as well as environmental or host factors converge in the gastroduodenal milieu and control the final outcome of infection. The host immune and inflammatory response is emerging as an important element in the pathogenesis of these gastric diseases. The ideal host response provides protection to clear an infection without causing excessive amounts of inflammation that could compromise the integrity and function of host cells. This review will cover four main questions: (1) What are the mucosal immune/inflammatory responses that confer protection without damaging the host? (2) How do the gastric immune responses during infection with H. pylori differ from this ideal scenario? (3) Do these responses contribute to autoimmune-mediated damage to gastric tissue? (4) Can immunomodulation through vaccination enhance protective, nondestructive responses that prevent or treat infection or, at least, attenuate inflammation?.

UR - http://www.scopus.com/inward/record.url?scp=0030774055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030774055&partnerID=8YFLogxK

M3 - Article

C2 - 9394758

AN - SCOPUS:0030774055

VL - 113

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6 SUPPL.

ER -