How important is the phosphatase activity of sensor kinases?

Research output: Contribution to journalReview articlepeer-review

50 Scopus citations


In two-component signaling systems, phosphorylated response regulators (RRs) are often dephosphorylated by their partner kinases in order to control the in vivo concentration of phospho-RR (RR∼P). This activity is easily demonstrated in vitro, but these experiments have typically used very high concentrations of the histidine kinase (HK) compared to the RR∼P. Many two-component systems exhibit exquisite control over the ratio of HK to RR in vivo. The question thus arises as to whether the phosphatase activity of HKs is significant in vivo. This topic will be explored in the present review.

Original languageEnglish (US)
Pages (from-to)168-176
Number of pages9
JournalCurrent Opinion in Microbiology
Issue number2
StatePublished - Apr 2010
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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