HTLV-I trans-activator protein, tax, is a trans-repressor of the human β-polymerase gene

Kuan Teh Jeang, Steven Widen, Oliver J. Semmes IV, Samuel H. Wilson

Research output: Contribution to journalArticle

280 Citations (Scopus)

Abstract

Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

Original languageEnglish (US)
Pages (from-to)1082-1084
Number of pages3
JournalScience
Volume247
Issue number4946
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

tax Gene Products
Human T-lymphotropic virus 1
Trans-Activators
Adult T Cell Leukemia Lymphoma
Genes
Viral Genes
Terminal Repeat Sequences
Virus Diseases
DNA Repair
Enzymes

ASJC Scopus subject areas

  • General

Cite this

HTLV-I trans-activator protein, tax, is a trans-repressor of the human β-polymerase gene. / Jeang, Kuan Teh; Widen, Steven; Semmes IV, Oliver J.; Wilson, Samuel H.

In: Science, Vol. 247, No. 4946, 01.01.1990, p. 1082-1084.

Research output: Contribution to journalArticle

Jeang, Kuan Teh ; Widen, Steven ; Semmes IV, Oliver J. ; Wilson, Samuel H. / HTLV-I trans-activator protein, tax, is a trans-repressor of the human β-polymerase gene. In: Science. 1990 ; Vol. 247, No. 4946. pp. 1082-1084.
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