HTLV-I trans-activator protein, tax, is a trans-repressor of the human β-polymerase gene

Kuan Teh Jeang, Steven Widen, Oliver J. Semmes IV, Samuel H. Wilson

Research output: Contribution to journalArticle

286 Scopus citations

Abstract

Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

Original languageEnglish (US)
Pages (from-to)1082-1084
Number of pages3
JournalScience
Volume247
Issue number4946
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • General

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