HTLV-I trans-activator protein, tax, is a transrepressor of the human β-polymerase gene

Kuan Teh Jeang; Steven G. Widen; Oliver J. Semmes IV; Samuel H. Wilson

HTLV-I trans-activator protein, tax, is a transrepressor of the human β-polymerase gene

Kuan Teh Jeang, Steven G. Widen, Oliver J. Semmes IV, Samuel H. Wilson

Research output: Contribution to journal › Article › peer-review

Abstract

Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax downregulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

Original language	English (US)
Pages (from-to)	1082-1084
Number of pages	3
Journal	Science
Volume	247
Issue number	4946
State	Published - Mar 2 1990
Externally published	Yes

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title = "HTLV-I trans-activator protein, tax, is a transrepressor of the human β-polymerase gene",

abstract = "Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax downregulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.",

author = "Jeang, {Kuan Teh} and Widen, {Steven G.} and {Semmes IV}, {Oliver J.} and Wilson, {Samuel H.}",

year = "1990",

month = mar,

day = "2",

language = "English (US)",

volume = "247",

pages = "1082--1084",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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T1 - HTLV-I trans-activator protein, tax, is a transrepressor of the human β-polymerase gene

AU - Jeang, Kuan Teh

AU - Widen, Steven G.

AU - Semmes IV, Oliver J.

AU - Wilson, Samuel H.

PY - 1990/3/2

Y1 - 1990/3/2

N2 - Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax downregulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

AB - Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax downregulated the expression of human β-polymerase (huβ-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

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M3 - Article

C2 - 2309119

AN - SCOPUS:0025355617

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VL - 247

SP - 1082

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JO - Science

JF - Science

IS - 4946

ER -

HTLV-I trans-activator protein, tax, is a transrepressor of the human β-polymerase gene

Abstract

ASJC Scopus subject areas

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