Human and Livestock Surveillance Revealed the Circulation of Rift Valley Fever Virus in Agnam, Northern Senegal, 2021

Moufid Mhamadi, Aminata Badji, Mamadou Aliou Barry, El Hadji Ndiaye, Alioune Gaye, Mignane Ndiaye, Moundhir Mhamadi, Cheikh Talibouya Touré, Oumar Ndiaye, Babacar Faye, Boly Diop, Mamadou Ndiaye, Mathioro Fall, Andy Mahine Diouf, Samba Niang Sagne, Cheikh Loucoubar, Hugues Fausther-Bovendo, Hugues Ara, Amadou Alpha Sall, Gary KobingerOusmane Faye, Mawlouth Diallo, Oumar Faye

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The mosquito-borne disease caused by the Rift Valley Fever Virus (RVFV) is a viral hemorrhagic fever that affects humans and animals. In 1987, RVFV emerged in Mauritania, which caused the first RVFV outbreak in West Africa. This outbreak was shortly followed by reported cases in humans and livestock in Senegal. Animal trade practices with neighboring Mauritania suggest northern regions of Senegal are at high risk for RVF. In this study, we aim to conduct a molecular and serological survey of RVFV in humans and livestock in Agnam (northeastern Senegal) by RT-PCR (reverse transcription real-time polymerase chain reaction) and ELISA (Enzyme-Linked Immunosorbent Assay), respectively. Of the two hundred fifty-five human sera, one (0.39%) tested RVFV IgM positive, while fifty-three (20.78%) tested positive for RVFV IgG. For animal monitoring, out of 30 sheep recorded and sampled over the study period, 20 (66.67%) showed seroconversion to RVFV IgG antibodies, notably during the rainy season. The presence of antibodies increased significantly with age in both groups (p < 0.05), as the force of RVF infection (FOI), increased by 16.05% per year for humans and by 80.4% per month for livestock sheep. This study supports the usefulness of setting up a One Health survey for RVF management.

Original languageEnglish (US)
Article number87
JournalTropical Medicine and Infectious Disease
Volume8
Issue number2
DOIs
StatePublished - Feb 2023

Keywords

  • Rift Valley Fever Virus
  • humans
  • livestock
  • northeastern Senegal
  • survey

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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