@article{78f9f84b4f5c4549a62035a9bc88fcff,
title = "Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function",
abstract = "Brown adipose tissue (BAT) plays an important role in mammalian thermoregulation. The component of BAT mitochondria that permits this function is the inner membrane carrier protein uncoupling protein 1 (UCP1). To the best of our knowledge, no studies have directly quantified UCP1 function in human BAT. Further, whether human and rodent BAT have comparable thermogenic function remains unknown. We employed high-resolution respirometry to determine the respiratory capacity, coupling control, and, most importantly, UCP1 function of human supraclavicular BAT and rodent interscapular BAT. Human BAT was sensitive to the purine nucleotide GDP, providing the first direct evidence that human BAT mitochondria have thermogenically functional UCP1. Further, our data demonstrate that human and rodent BAT have similar UCP1 function per mitochondrion. These data indicate that human and rodent BAT are qualitatively similar in terms of UCP1 function.",
author = "Craig Porter and David Herndon and Maria Chondronikola and Tony Chao and Palam Annamalai and Nisha Bhattarai and Saraf, {Manish K.} and Capek, {Karel D.} and Reidy, {Paul T.} and Daquinag, {Alexes C.} and Kolonin, {Mikhail G.} and Rasmussen, {Blake B.} and Elisabet Borsheim and Tracy Toliver-Kinsky and Labros Sidossis",
note = "Funding Information: This work was supported by grants from the NIH (P30 AG024832, RO1 AR049877, and P50 GM060388), American Diabetes Association (1-14-TS-35), Shriners Hospitals for Children (84090, 85310, and 84510), and the Department of Surgery at UTMB. Study visits were conducted with the support of the Institute for Translational Sciences at UTMB, which is supported by a Clinical and Translational Science Award (UL1TR000071) from the National Center for Advancing Translational Sciences, NIH. C.P. was supported by a training grant (H133P110012) from the National Institute for Disabilities and Rehabilitation Research and the Department of Education. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2016",
month = aug,
day = "9",
doi = "10.1016/j.cmet.2016.07.004",
language = "English (US)",
volume = "24",
pages = "246--255",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",
}