Human and rodent hantavirus infection in New York State

Public health significance of an emerging infectious disease

Dennis J. White, Robert G. Means, Guthrie S. Birkhead, Edward M. Bosler, Leo J. Grady, Nando Chatterjee, Jack Woodall, Brian Hjelle, Pierre E. Rollin, Thomas Ksiazek, Dale L. Morse

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: A case of hantavirus pulmonary syndrome with possible exposure in New York and/or Rhode Island was confirmed in February 1994. Objective: To conduct four studies to determine the historical and geographic distribution of human and small-mammal infection with hantaviruses in New York State. Methods: Enzyme-linked immunosorbent assays were performed on serum samples obtained from 130 humans during a 1978 babesiosis survey, 907 small mammals collected in New York State since 1984, 12 rodents collected in 1994 near the residences of the patients with hantavirus pulmonary syndrome, and 76 New York patients with acute respiratory distress syndrome-like illness (as suspected cases of hantavirus pulmonary syndrome). Results: None of the human serum samples from the 1978 serosurvey showed evidence of hantavirus exposure by enzyme-linked immunosorbent assay. State-wide historical serum samples from white-footed mice showed evidence of Sin Nombre virus infection in 12.0% (97/809) and Seoul-like virus infection in 9.6% (78/809). Site-specific seropositivity rates were as high as 48.5% with Sin Nombre virus during 1 year (1984). Two of 12 mice captured near the residences of a human patient were positive for Sin Nombre virus by enzyme-linked immunosorbent assay, yet were negative for viral RNA by polymerase chain reaction. None of the patients with suspected hantavirus pulmonary syndrome was serologically reactive for Sin Nombre virus. Conclusions: We provide serologic evidence of small-mammal infection with hantaviruses in New York State as long ago as 1984. Human cases of hantavirus pulmonary syndrome are rare in New York, and data indicate that transmission to humans is probably infrequent. A unique set of host, agent, and environmental factors may be necessary to cause hantavirus pulmonary syndrome in humans.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
JournalArchives of Internal Medicine
Volume156
Issue number7
DOIs
StatePublished - Apr 8 1996
Externally publishedYes

Fingerprint

Hantavirus Infections
Emerging Communicable Diseases
Hantavirus Pulmonary Syndrome
Sin Nombre virus
Rodentia
Public Health
Mammals
Enzyme-Linked Immunosorbent Assay
Virus Diseases
Seoul virus
Serum
Peromyscus
Hantavirus
Babesiosis
Adult Respiratory Distress Syndrome
Viral RNA
DNA-Directed RNA Polymerases
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Internal Medicine

Cite this

White, D. J., Means, R. G., Birkhead, G. S., Bosler, E. M., Grady, L. J., Chatterjee, N., ... Morse, D. L. (1996). Human and rodent hantavirus infection in New York State: Public health significance of an emerging infectious disease. Archives of Internal Medicine, 156(7), 722-726. https://doi.org/10.1001/archinte.156.7.722

Human and rodent hantavirus infection in New York State : Public health significance of an emerging infectious disease. / White, Dennis J.; Means, Robert G.; Birkhead, Guthrie S.; Bosler, Edward M.; Grady, Leo J.; Chatterjee, Nando; Woodall, Jack; Hjelle, Brian; Rollin, Pierre E.; Ksiazek, Thomas; Morse, Dale L.

In: Archives of Internal Medicine, Vol. 156, No. 7, 08.04.1996, p. 722-726.

Research output: Contribution to journalArticle

White, DJ, Means, RG, Birkhead, GS, Bosler, EM, Grady, LJ, Chatterjee, N, Woodall, J, Hjelle, B, Rollin, PE, Ksiazek, T & Morse, DL 1996, 'Human and rodent hantavirus infection in New York State: Public health significance of an emerging infectious disease', Archives of Internal Medicine, vol. 156, no. 7, pp. 722-726. https://doi.org/10.1001/archinte.156.7.722
White, Dennis J. ; Means, Robert G. ; Birkhead, Guthrie S. ; Bosler, Edward M. ; Grady, Leo J. ; Chatterjee, Nando ; Woodall, Jack ; Hjelle, Brian ; Rollin, Pierre E. ; Ksiazek, Thomas ; Morse, Dale L. / Human and rodent hantavirus infection in New York State : Public health significance of an emerging infectious disease. In: Archives of Internal Medicine. 1996 ; Vol. 156, No. 7. pp. 722-726.
@article{f6f31f6bb78547d5b04f5da5e9771007,
title = "Human and rodent hantavirus infection in New York State: Public health significance of an emerging infectious disease",
abstract = "Background: A case of hantavirus pulmonary syndrome with possible exposure in New York and/or Rhode Island was confirmed in February 1994. Objective: To conduct four studies to determine the historical and geographic distribution of human and small-mammal infection with hantaviruses in New York State. Methods: Enzyme-linked immunosorbent assays were performed on serum samples obtained from 130 humans during a 1978 babesiosis survey, 907 small mammals collected in New York State since 1984, 12 rodents collected in 1994 near the residences of the patients with hantavirus pulmonary syndrome, and 76 New York patients with acute respiratory distress syndrome-like illness (as suspected cases of hantavirus pulmonary syndrome). Results: None of the human serum samples from the 1978 serosurvey showed evidence of hantavirus exposure by enzyme-linked immunosorbent assay. State-wide historical serum samples from white-footed mice showed evidence of Sin Nombre virus infection in 12.0{\%} (97/809) and Seoul-like virus infection in 9.6{\%} (78/809). Site-specific seropositivity rates were as high as 48.5{\%} with Sin Nombre virus during 1 year (1984). Two of 12 mice captured near the residences of a human patient were positive for Sin Nombre virus by enzyme-linked immunosorbent assay, yet were negative for viral RNA by polymerase chain reaction. None of the patients with suspected hantavirus pulmonary syndrome was serologically reactive for Sin Nombre virus. Conclusions: We provide serologic evidence of small-mammal infection with hantaviruses in New York State as long ago as 1984. Human cases of hantavirus pulmonary syndrome are rare in New York, and data indicate that transmission to humans is probably infrequent. A unique set of host, agent, and environmental factors may be necessary to cause hantavirus pulmonary syndrome in humans.",
author = "White, {Dennis J.} and Means, {Robert G.} and Birkhead, {Guthrie S.} and Bosler, {Edward M.} and Grady, {Leo J.} and Nando Chatterjee and Jack Woodall and Brian Hjelle and Rollin, {Pierre E.} and Thomas Ksiazek and Morse, {Dale L.}",
year = "1996",
month = "4",
day = "8",
doi = "10.1001/archinte.156.7.722",
language = "English (US)",
volume = "156",
pages = "722--726",
journal = "JAMA Internal Medicine",
issn = "2168-6106",
publisher = "American Medical Association",
number = "7",

}

TY - JOUR

T1 - Human and rodent hantavirus infection in New York State

T2 - Public health significance of an emerging infectious disease

AU - White, Dennis J.

AU - Means, Robert G.

AU - Birkhead, Guthrie S.

AU - Bosler, Edward M.

AU - Grady, Leo J.

AU - Chatterjee, Nando

AU - Woodall, Jack

AU - Hjelle, Brian

AU - Rollin, Pierre E.

AU - Ksiazek, Thomas

AU - Morse, Dale L.

PY - 1996/4/8

Y1 - 1996/4/8

N2 - Background: A case of hantavirus pulmonary syndrome with possible exposure in New York and/or Rhode Island was confirmed in February 1994. Objective: To conduct four studies to determine the historical and geographic distribution of human and small-mammal infection with hantaviruses in New York State. Methods: Enzyme-linked immunosorbent assays were performed on serum samples obtained from 130 humans during a 1978 babesiosis survey, 907 small mammals collected in New York State since 1984, 12 rodents collected in 1994 near the residences of the patients with hantavirus pulmonary syndrome, and 76 New York patients with acute respiratory distress syndrome-like illness (as suspected cases of hantavirus pulmonary syndrome). Results: None of the human serum samples from the 1978 serosurvey showed evidence of hantavirus exposure by enzyme-linked immunosorbent assay. State-wide historical serum samples from white-footed mice showed evidence of Sin Nombre virus infection in 12.0% (97/809) and Seoul-like virus infection in 9.6% (78/809). Site-specific seropositivity rates were as high as 48.5% with Sin Nombre virus during 1 year (1984). Two of 12 mice captured near the residences of a human patient were positive for Sin Nombre virus by enzyme-linked immunosorbent assay, yet were negative for viral RNA by polymerase chain reaction. None of the patients with suspected hantavirus pulmonary syndrome was serologically reactive for Sin Nombre virus. Conclusions: We provide serologic evidence of small-mammal infection with hantaviruses in New York State as long ago as 1984. Human cases of hantavirus pulmonary syndrome are rare in New York, and data indicate that transmission to humans is probably infrequent. A unique set of host, agent, and environmental factors may be necessary to cause hantavirus pulmonary syndrome in humans.

AB - Background: A case of hantavirus pulmonary syndrome with possible exposure in New York and/or Rhode Island was confirmed in February 1994. Objective: To conduct four studies to determine the historical and geographic distribution of human and small-mammal infection with hantaviruses in New York State. Methods: Enzyme-linked immunosorbent assays were performed on serum samples obtained from 130 humans during a 1978 babesiosis survey, 907 small mammals collected in New York State since 1984, 12 rodents collected in 1994 near the residences of the patients with hantavirus pulmonary syndrome, and 76 New York patients with acute respiratory distress syndrome-like illness (as suspected cases of hantavirus pulmonary syndrome). Results: None of the human serum samples from the 1978 serosurvey showed evidence of hantavirus exposure by enzyme-linked immunosorbent assay. State-wide historical serum samples from white-footed mice showed evidence of Sin Nombre virus infection in 12.0% (97/809) and Seoul-like virus infection in 9.6% (78/809). Site-specific seropositivity rates were as high as 48.5% with Sin Nombre virus during 1 year (1984). Two of 12 mice captured near the residences of a human patient were positive for Sin Nombre virus by enzyme-linked immunosorbent assay, yet were negative for viral RNA by polymerase chain reaction. None of the patients with suspected hantavirus pulmonary syndrome was serologically reactive for Sin Nombre virus. Conclusions: We provide serologic evidence of small-mammal infection with hantaviruses in New York State as long ago as 1984. Human cases of hantavirus pulmonary syndrome are rare in New York, and data indicate that transmission to humans is probably infrequent. A unique set of host, agent, and environmental factors may be necessary to cause hantavirus pulmonary syndrome in humans.

UR - http://www.scopus.com/inward/record.url?scp=13344277354&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13344277354&partnerID=8YFLogxK

U2 - 10.1001/archinte.156.7.722

DO - 10.1001/archinte.156.7.722

M3 - Article

VL - 156

SP - 722

EP - 726

JO - JAMA Internal Medicine

JF - JAMA Internal Medicine

SN - 2168-6106

IS - 7

ER -