Human ehrlichioses: Diagnostic challenges and therapeutic recommendations

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The clinical spectrum of human ehrlichioses ranges from mild febrile illnesses to fatal infections. Laboratory diagnosis of these diseases is based on immunofluorescent assays (IFAs) and therefore requires a convalescent serum sample to demonstrate seroconversion or rising antibody titers. More sophisticated techniques, such as Western immunoblotting using recombinant proteins, show great promise. Diagnosis during the acute phase, in which IFA is usually nondiagnostic, is based on polymerase chain reaction assays. Cultivation of the organisms is difficult and impractical. The treatment of choice is a tetracycline; within this group, doxycycline is the preferred drug because of its better tolerance and lower incidence of side effects.

Original languageEnglish (US)
Pages (from-to)318-325
Number of pages8
JournalInfections in Medicine
Volume19
Issue number7
StatePublished - 2002

Fingerprint

Ehrlichiosis
Doxycycline
Clinical Laboratory Techniques
Tetracycline
Recombinant Proteins
Fever
Western Blotting
Polymerase Chain Reaction
Antibodies
Incidence
Infection
Serum
Pharmaceutical Preparations
Therapeutics
Seroconversion

Keywords

  • Anaplasma phagocytophila
  • Ehrlichia chaffeensis
  • Ehrlichia ewingii
  • Ehrlichiosis

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Human ehrlichioses : Diagnostic challenges and therapeutic recommendations. / Olano, Juan; Walker, David.

In: Infections in Medicine, Vol. 19, No. 7, 2002, p. 318-325.

Research output: Contribution to journalArticle

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