Human erythrocyte glutathione s-transferase: A possible marker of chemical exposure

Ghulam Ansari, Shivendra V. Singh, Jose C. Gan, Y. C. Awasthi

Research output: Contribution to journalArticle

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Abstract

We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalToxicology Letters
Volume37
Issue number1
DOIs
StatePublished - 1987

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Keywords

  • 1,2-dihaloethanes
  • acrolein
  • Biological marker
  • chemical exposure
  • epoxides
  • industrial toxicants

ASJC Scopus subject areas

  • Toxicology

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