Human erythrocyte glutathione s-transferase

A possible marker of chemical exposure

Ghulam Ansari, Shivendra V. Singh, Jose C. Gan, Y. C. Awasthi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.

Original languageEnglish (US)
Pages (from-to)57-62
Number of pages6
JournalToxicology Letters
Volume37
Issue number1
DOIs
StatePublished - 1987

Fingerprint

Transferases
Glutathione Transferase
Glutathione
styrene oxide
Erythrocytes
Ethylene Dibromide
Acrolein
Biomarkers

Keywords

  • 1,2-dihaloethanes
  • acrolein
  • Biological marker
  • chemical exposure
  • epoxides
  • industrial toxicants

ASJC Scopus subject areas

  • Toxicology

Cite this

Human erythrocyte glutathione s-transferase : A possible marker of chemical exposure. / Ansari, Ghulam; Singh, Shivendra V.; Gan, Jose C.; Awasthi, Y. C.

In: Toxicology Letters, Vol. 37, No. 1, 1987, p. 57-62.

Research output: Contribution to journalArticle

Ansari, Ghulam ; Singh, Shivendra V. ; Gan, Jose C. ; Awasthi, Y. C. / Human erythrocyte glutathione s-transferase : A possible marker of chemical exposure. In: Toxicology Letters. 1987 ; Vol. 37, No. 1. pp. 57-62.
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