Human erythrocyte glutathione s-transferase: A possible marker of chemical exposure

G. A.S. Ansari; Shivendra V. Singh; Jose C. Gan; Y. C. Awasthi

doi:10.1016/0378-4274(87)90167-6

Human erythrocyte glutathione s-transferase: A possible marker of chemical exposure

G. A.S. Ansari
, Shivendra V. Singh
, Jose C. Gan
, Y. C. Awasthi

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.

Original language	English (US)
Pages (from-to)	57-62
Number of pages	6
Journal	Toxicology Letters
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/0378-4274(87)90167-6
State	Published - Jun 1987
Externally published	Yes

Keywords

1,2-dihaloethanes
Biological marker
acrolein
chemical exposure
epoxides
industrial toxicants

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(87)90167-6

Cite this

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title = "Human erythrocyte glutathione s-transferase: A possible marker of chemical exposure",

abstract = "We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.",

keywords = "1,2-dihaloethanes, Biological marker, acrolein, chemical exposure, epoxides, industrial toxicants",

author = "Ansari, \{G. A.S.\} and Singh, \{Shivendra V.\} and Gan, \{Jose C.\} and Awasthi, \{Y. C.\}",

note = "Funding Information: This investigation was supported in part by grant OH 02149, awarded by the National Institute for Occupational Safety and Health of the Centers for Disease Control; U.S.P.H.S. grant AM 27135, awarded by the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases; grant GM 32304, awarded by the National Institute of General Medical Sciences; grant CA 27967, awarded by the National Cancer Institute; and grant EY 04396, awarded by the National Eye Institute. Technical assistance of Thelma Lea1 and Geralyn Creadon is also acknowledged.",

year = "1987",

month = jun,

doi = "10.1016/0378-4274(87)90167-6",

language = "English (US)",

volume = "37",

pages = "57--62",

journal = "Toxicology Letters",

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TY - JOUR

T1 - Human erythrocyte glutathione s-transferase

T2 - A possible marker of chemical exposure

AU - Ansari, G. A.S.

AU - Singh, Shivendra V.

AU - Gan, Jose C.

AU - Awasthi, Y. C.

N1 - Funding Information: This investigation was supported in part by grant OH 02149, awarded by the National Institute for Occupational Safety and Health of the Centers for Disease Control; U.S.P.H.S. grant AM 27135, awarded by the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases; grant GM 32304, awarded by the National Institute of General Medical Sciences; grant CA 27967, awarded by the National Cancer Institute; and grant EY 04396, awarded by the National Eye Institute. Technical assistance of Thelma Lea1 and Geralyn Creadon is also acknowledged.

PY - 1987/6

Y1 - 1987/6

N2 - We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.

AB - We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.

KW - 1,2-dihaloethanes

KW - Biological marker

KW - acrolein

KW - chemical exposure

KW - epoxides

KW - industrial toxicants

UR - https://www.scopus.com/pages/publications/0023179643

UR - https://www.scopus.com/pages/publications/0023179643#tab=citedBy

U2 - 10.1016/0378-4274(87)90167-6

DO - 10.1016/0378-4274(87)90167-6

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AN - SCOPUS:0023179643

SN - 0378-4274

VL - 37

SP - 57

EP - 62

JO - Toxicology Letters

JF - Toxicology Letters

IS - 1

ER -

Human erythrocyte glutathione s-transferase: A possible marker of chemical exposure

Abstract

Keywords

ASJC Scopus subject areas

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