Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture

J. A. Levy; A. Landay; E. T. Lennette

doi:10.1128/jcm.28.10.2362-2364.1990

Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture

J. A. Levy, A. Landay, E. T. Lennette

Research output: Contribution to journal › Article › peer-review

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Abstract

The SF strain of human herpesvirus 6 (HHV-6(SF)) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4⁺ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4⁺ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.

Original language	English (US)
Pages (from-to)	2362-2364
Number of pages	3
Journal	Journal of Clinical Microbiology
Volume	28
Issue number	10
DOIs	https://doi.org/10.1128/jcm.28.10.2362-2364.1990
State	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/jcm.28.10.2362-2364.1990

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title = "Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture",

abstract = "The SF strain of human herpesvirus 6 (HHV-6(SF)) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4+ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.",

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year = "1990",

doi = "10.1128/jcm.28.10.2362-2364.1990",

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AU - Levy, J. A.

AU - Landay, A.

AU - Lennette, E. T.

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N2 - The SF strain of human herpesvirus 6 (HHV-6(SF)) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4+ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.

AB - The SF strain of human herpesvirus 6 (HHV-6(SF)) isolated from the saliva of a human immunodeficiency virus (HIV)-infected individual was shown to inhibit HIV type 1 (HIV-1) replication in both peripheral blood mononuclear cells and purified CD4+ lymphocytes. This suppression of HIV-1 replication led to decreased cytopathic effects of HIV-1 and prolonged survival of CD4+ cells in culture. Even low levels of HHV-6 added to peripheral blood mononuclear cells showed an inhibitory effect an inhibitory effect on HIV-1 replication. These results differ from those previously reported showing enhanced HIV-1 production following infection with another strain of HHV-6.

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Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture

Abstract

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