Human immune interferon

Induction in lymphoid cells by a calcium ionophore

F. Dianzani, T. M. Monahan, J. Georgiades, J. B. Alperin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Human lymphocyte cultures produced interferon after treatment with the calcium ionophore A23187, but not after treatment with potassium ionophore nonactin. Interferon production was detectable between 3 and 6 h after ionophore treatment and reached the maximum level between 12 and 24 h. Ionophore-induced interferon appeared to be immune interferon on the basis of acid lability, lack of neutralization by antibody to leukocyte interferon, slow kinetics of activation of the antiviral state, and molecular characterization by isoelectrofocusing.

Original languageEnglish (US)
Pages (from-to)561-563
Number of pages3
JournalInfection and Immunity
Volume29
Issue number2
StatePublished - 1980

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Calcium Ionophores
Interferons
Interferon-gamma
Ionophores
Lymphocytes
Potassium Ionophores
Calcimycin
Interferon-alpha
Antiviral Agents
Acids
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Dianzani, F., Monahan, T. M., Georgiades, J., & Alperin, J. B. (1980). Human immune interferon: Induction in lymphoid cells by a calcium ionophore. Infection and Immunity, 29(2), 561-563.

Human immune interferon : Induction in lymphoid cells by a calcium ionophore. / Dianzani, F.; Monahan, T. M.; Georgiades, J.; Alperin, J. B.

In: Infection and Immunity, Vol. 29, No. 2, 1980, p. 561-563.

Research output: Contribution to journalArticle

Dianzani, F, Monahan, TM, Georgiades, J & Alperin, JB 1980, 'Human immune interferon: Induction in lymphoid cells by a calcium ionophore', Infection and Immunity, vol. 29, no. 2, pp. 561-563.
Dianzani F, Monahan TM, Georgiades J, Alperin JB. Human immune interferon: Induction in lymphoid cells by a calcium ionophore. Infection and Immunity. 1980;29(2):561-563.
Dianzani, F. ; Monahan, T. M. ; Georgiades, J. ; Alperin, J. B. / Human immune interferon : Induction in lymphoid cells by a calcium ionophore. In: Infection and Immunity. 1980 ; Vol. 29, No. 2. pp. 561-563.
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