Human macrophage responses to vaccine strains of influenza virus: synthesis of viral proteins, interleukin-1β, interleukin-6, tumour necrosis factor-α and interleukin-1 inhibitor

Joan E. Nichols, Theresa F. Fitzgerald, Norbert J. Roberts

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Interactions between influenza viruses and human macrophages were examined to detect potential mechanisms for enhanced febrile reactions previously associated with administration of an avian-human H1N1 reassortant vaccine. Cells exposed to that strain were compared with cells exposed to wild-type and cold-adapted H1H1 and H3H2 strains and an avian-human H3N2 strain. Cells exposed to the avian-human H1N1 virus showed increased synthesis of viral neuraminidase, previously reported to induce fever-producing cytokines, but no detectable increase in production of interleukin-1β, interleukin-6 and tumour necrosis factor-α measured by immunoassay, or decrease in interleukin-1 inhibitor activity by bioassay.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalVaccine
Volume11
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Influenza virus
  • enhanced febrile reaction
  • human macrophages

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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