Human macrophage responses to vaccine strains of influenza virus: synthesis of viral proteins, interleukin-1β, interleukin-6, tumour necrosis factor-α and interleukin-1 inhibitor

Joan E. Nichols, Theresa F. Fitzgerald, Norbert J. Roberts

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Interactions between influenza viruses and human macrophages were examined to detect potential mechanisms for enhanced febrile reactions previously associated with administration of an avian-human H1N1 reassortant vaccine. Cells exposed to that strain were compared with cells exposed to wild-type and cold-adapted H1H1 and H3H2 strains and an avian-human H3N2 strain. Cells exposed to the avian-human H1N1 virus showed increased synthesis of viral neuraminidase, previously reported to induce fever-producing cytokines, but no detectable increase in production of interleukin-1β, interleukin-6 and tumour necrosis factor-α measured by immunoassay, or decrease in interleukin-1 inhibitor activity by bioassay.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalVaccine
Volume11
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Influenza virus
  • enhanced febrile reaction
  • human macrophages

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Human macrophage responses to vaccine strains of influenza virus: synthesis of viral proteins, interleukin-1β, interleukin-6, tumour necrosis factor-α and interleukin-1 inhibitor'. Together they form a unique fingerprint.

  • Cite this