Human macrophage responses to vaccine strains of influenza virus

synthesis of viral proteins, interleukin-1β, interleukin-6, tumour necrosis factor-α and interleukin-1 inhibitor

Joan Nichols, Theresa F. Fitzgerald, Norbert J. Roberts

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Interactions between influenza viruses and human macrophages were examined to detect potential mechanisms for enhanced febrile reactions previously associated with administration of an avian-human H1N1 reassortant vaccine. Cells exposed to that strain were compared with cells exposed to wild-type and cold-adapted H1H1 and H3H2 strains and an avian-human H3N2 strain. Cells exposed to the avian-human H1N1 virus showed increased synthesis of viral neuraminidase, previously reported to induce fever-producing cytokines, but no detectable increase in production of interleukin-1β, interleukin-6 and tumour necrosis factor-α measured by immunoassay, or decrease in interleukin-1 inhibitor activity by bioassay.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalVaccine
Volume11
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

tumor necrosis factors
Influenza Vaccines
viral proteins
interleukin-1
Viral Proteins
Orthomyxoviridae
Interleukin-1
interleukin-6
Interleukin-6
macrophages
Tumor Necrosis Factor-alpha
Macrophages
vaccines
synthesis
fever
Fever
H1N1 Subtype Influenza A Virus
sialidase
Neuraminidase
cells

Keywords

  • enhanced febrile reaction
  • human macrophages
  • Influenza virus

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Human macrophage responses to vaccine strains of influenza virus : synthesis of viral proteins, interleukin-1β, interleukin-6, tumour necrosis factor-α and interleukin-1 inhibitor. / Nichols, Joan; Fitzgerald, Theresa F.; Roberts, Norbert J.

In: Vaccine, Vol. 11, No. 1, 1993, p. 36-42.

Research output: Contribution to journalArticle

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