Human metapneumovirus antagonism of innate immune responses

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Human metapneumovirus (hMPV) is a recently identified RNA virus belonging to the Paramyxoviridae family, which includes several major human and animal pathogens. Epidemiological studies indicate that hMPV is a significant human respiratory pathogen with worldwide distribution. It is associated with respiratory illnesses in children, adults, and immunocompromised patients, ranging from upper respiratory tract infections to severe bronchiolitis and pneumonia. Interferon (IFN) represents a major line of defense against virus infection, and in response, viruses have evolved countermeasures to inhibit IFN production as well as IFN signaling. Although the strategies of IFN evasion are similar, the specific mechanisms by which paramyxoviruses inhibit IFN responses are quite diverse. In this review, we will present an overview of the strategies that hMPV uses to subvert cellular signaling in airway epithelial cells, the major target of infection, as well as in primary immune cells.

Original languageEnglish (US)
Pages (from-to)3551-3571
Number of pages21
JournalViruses
Volume4
Issue number12
DOIs
StatePublished - Dec 7 2012

Keywords

  • Innate immune system
  • Interferon antagonism
  • Metapneumovirus
  • Viral proteins

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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