Human metapneumovirus in turkey poults

Binu T. Velayudhan; Kakambi V. Nagaraja; Anil J. Thachil; Daniel P. Shaw; Gregory C. Gray; David A. Halvorson

doi:10.3201/eid1212.060450

Human metapneumovirus in turkey poults

Binu T. Velayudhan
, Kakambi V. Nagaraja
, Anil J. Thachil
, Daniel P. Shaw
, Gregory C. Gray
, David A. Halvorson

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

This study was conducted to reexamine the hypothesis that human metapneumovirus (hMPV) will not infect turkeys. Six groups of 2-week-old turkeys (20 per group) were inoculated oculonasally with 1 of the following: noninfected cell suspension; hMPV genotype A1, A2, B1, or B2; or avian metapneumovirus (aMPV) subtype C. Poults inoculated with hMPV showed nasal discharge days 4-9 post-exposure. Specific viral RNA and antigen were detected by reverse-transcription PCR and immunohistochemical evaluation, respectively, in nasal turbinates of birds exposed to hMPV. Nasal turbinates of hMPV-infected turkeys showed inflammatory changes and mucus accumulation. Each of the 4 hMPV genotypes caused a transient infection in turkeys as evidenced by clinical signs, detection of hMPV in turbinates, and histopathologic examination. Detailed investigation of cross-species pathogenicity of hMPV and aMPV and its importance for human and animal health is needed.

Original language	English (US)
Pages (from-to)	1853-1859
Number of pages	7
Journal	Emerging infectious diseases
Volume	12
Issue number	12
DOIs	https://doi.org/10.3201/eid1212.060450
State	Published - Dec 2006
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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title = "Human metapneumovirus in turkey poults",

abstract = "This study was conducted to reexamine the hypothesis that human metapneumovirus (hMPV) will not infect turkeys. Six groups of 2-week-old turkeys (20 per group) were inoculated oculonasally with 1 of the following: noninfected cell suspension; hMPV genotype A1, A2, B1, or B2; or avian metapneumovirus (aMPV) subtype C. Poults inoculated with hMPV showed nasal discharge days 4-9 post-exposure. Specific viral RNA and antigen were detected by reverse-transcription PCR and immunohistochemical evaluation, respectively, in nasal turbinates of birds exposed to hMPV. Nasal turbinates of hMPV-infected turkeys showed inflammatory changes and mucus accumulation. Each of the 4 hMPV genotypes caused a transient infection in turkeys as evidenced by clinical signs, detection of hMPV in turbinates, and histopathologic examination. Detailed investigation of cross-species pathogenicity of hMPV and aMPV and its importance for human and animal health is needed.",

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AU - Velayudhan, Binu T.

AU - Nagaraja, Kakambi V.

AU - Thachil, Anil J.

AU - Shaw, Daniel P.

AU - Gray, Gregory C.

AU - Halvorson, David A.

PY - 2006/12

Y1 - 2006/12

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AB - This study was conducted to reexamine the hypothesis that human metapneumovirus (hMPV) will not infect turkeys. Six groups of 2-week-old turkeys (20 per group) were inoculated oculonasally with 1 of the following: noninfected cell suspension; hMPV genotype A1, A2, B1, or B2; or avian metapneumovirus (aMPV) subtype C. Poults inoculated with hMPV showed nasal discharge days 4-9 post-exposure. Specific viral RNA and antigen were detected by reverse-transcription PCR and immunohistochemical evaluation, respectively, in nasal turbinates of birds exposed to hMPV. Nasal turbinates of hMPV-infected turkeys showed inflammatory changes and mucus accumulation. Each of the 4 hMPV genotypes caused a transient infection in turkeys as evidenced by clinical signs, detection of hMPV in turbinates, and histopathologic examination. Detailed investigation of cross-species pathogenicity of hMPV and aMPV and its importance for human and animal health is needed.

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ER -

Human metapneumovirus in turkey poults

Abstract

ASJC Scopus subject areas

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