Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus

Antonieta Guerrero-Plata, Antonella Casola, Roberto P. Garofalo

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovinis (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent indecer of granulocytc-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-α) and IFN-ã responses than RSV. In regard to immunomodelatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.

Original languageEnglish (US)
Pages (from-to)14992-14997
Number of pages6
JournalJournal of virology
Volume79
Issue number23
DOIs
StatePublished - Dec 1 2005

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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