Abstract
Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovinis (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent indecer of granulocytc-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-α) and IFN-ã responses than RSV. In regard to immunomodelatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 14992-14997 |
| Number of pages | 6 |
| Journal | Journal of Virology |
| Volume | 79 |
| Issue number | 23 |
| DOIs | |
| State | Published - Dec 2005 |
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ASJC Scopus subject areas
- Immunology
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Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus. / Guerrero-Plata, Antonieta; Casola, Antonella; Garofalo, Roberto.
In: Journal of Virology, Vol. 79, No. 23, 12.2005, p. 14992-14997.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus
AU - Guerrero-Plata, Antonieta
AU - Casola, Antonella
AU - Garofalo, Roberto
PY - 2005/12
Y1 - 2005/12
N2 - Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovinis (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent indecer of granulocytc-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-α) and IFN-ã responses than RSV. In regard to immunomodelatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.
AB - Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovinis (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent indecer of granulocytc-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-α) and IFN-ã responses than RSV. In regard to immunomodelatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.
UR - http://www.scopus.com/inward/record.url?scp=27744449447&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27744449447&partnerID=8YFLogxK
U2 - 10.1128/JVI.79.23.14992-14997.2005
DO - 10.1128/JVI.79.23.14992-14997.2005
M3 - Article
C2 - 16282501
AN - SCOPUS:27744449447
VL - 79
SP - 14992
EP - 14997
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 23
ER -