Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovinis (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent indecer of granulocytc-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-α) and IFN-ã responses than RSV. In regard to immunomodelatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of virology|
|State||Published - Dec 1 2005|
ASJC Scopus subject areas
- Insect Science