Abstract
Lung cytokine and chemokine production by BALB/c mice infected with human metapneumovinis (hMPV) was compared to respiratory syncytial virus (RSV)-infected mice. hMPV infection induced lower levels of the inflammatory cytokines interleukin-1 (IL-1), IL-6 and tumor necrosis factor alpha but was a more potent indecer of granulocytc-macrophage colony-stimulating factor and triggered a more sustained production of the CXC chemokine KC compared to RSV. hMPV was a stronger inducer of both alpha interferon (IFN-α) and IFN-ã responses than RSV. In regard to immunomodelatory cytokines, hMPV failed to induce detectable IL-10 or IL-12p70 but was a potent inducer of IL-12 p40 subunit. The implications for hMPV pathogenesis are discussed.
Original language | English (US) |
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Pages (from-to) | 14992-14997 |
Number of pages | 6 |
Journal | Journal of virology |
Volume | 79 |
Issue number | 23 |
DOIs | |
State | Published - Dec 2005 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology