Human metapneumovirus infections among children with acute respiratory infections seen in a large referral hospital in India

Sagarika Banerjee, Preeti Bharaj, Wayne Sullender, Sushil K. Kabra, Shobha Broor

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background: Acute respiratory infections (ARI) are the leading cause of morbidity and mortality among children <5 years of age in developing countries. Human metapneumovirus (hMPV), a newly described respiratory pathogen, has been identified as an important cause of ARI in young children. Objectives: The objective was to describe the prevalence of hMPV in children who presented with ARI to a large referral hospital in Delhi, India and to genotype circulating strains on the basis of F gene nucleotide sequence analysis. Study design: We analyzed 97 samples from children <5 years of age with ARI seen at the All India Institute of Medical Sciences from June 2004 to March 2005. RT-PCR was performed for the N and F genes and partial F gene nucleotide sequences were used to characterize the viruses. Results: hMPV was identified in 12% of children with ARI, including 13% of the children hospitalized with ARI. Most virus identification occurred in the winter. The Indian strains clustered in the A2 genetic sublineage. Conclusions: This report establishes hMPV as an important cause of ARI in children in India.

Original languageEnglish (US)
Pages (from-to)70-72
Number of pages3
JournalJournal of Clinical Virology
Volume38
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Acute respiratory infection
  • Fusion protein gene
  • Human metapneumovirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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