Human Metapneumovirus (Pneumoviridae)

Antonella Casola, Matteo P. Garofalo, Xiaoyong Bao

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Human metapneumovirus (hMPV) is a negative-sense, single-stranded RNA virus, belonging to the Metapneumovirus genus of the family Pneumoviridae. It is one of the major causes of acute respiratory tract infection in the pediatric population, in immunocompromised patients and in older adults worldwide, for which no specific prevention and treatment is currently available. Immunity is incomplete, and reinfections occur throughout the life. This article mainly focuses on summarizing the current knowledge on hMPV epidemiology, clinical disease, pathogenetic mechanisms, strategies for disease prevention and medical treatment, as well as potential future vaccination and therapeutic approaches.

    Original languageEnglish (US)
    Title of host publicationEncyclopedia of Virology
    Subtitle of host publicationVolume 1-5, Fourth Edition
    PublisherElsevier
    Pages475-482
    Number of pages8
    Volume1-5
    ISBN (Electronic)9780128145166
    DOIs
    StatePublished - Jan 1 2020

    Keywords

    • Airway epithelial cells (AECs)
    • Dendritic cells (DCs)
    • Endosomal sorting complex required for transport (ESCRT)
    • Human metapnemovirus (hMPV)
    • Human RSV (hRSV)
    • Inclusion bodies (IBs)
    • Interferon (IFN)
    • Intravenous immunoglobulins (IVIG)
    • Lower respiratory tract infection (LRTI)
    • NOD-like receptors (NLRs)
    • Pathogen-associated molecular pattern (PAMP)
    • Pattern recognition receptors (PRRs)
    • Real-time reverse transcriptase-polymerase chain reaction (RT-PCR)
    • RIG-I-like receptors (RLRs)
    • RNA-dependent RNA polymerase (RdRp)
    • Single-stranded RNA (ssRNA)
    • Toll-like receptors (TLRs)
    • Upper respiratory tract infection (URTI)

    ASJC Scopus subject areas

    • Immunology and Microbiology(all)

    Fingerprint

    Dive into the research topics of 'Human Metapneumovirus (Pneumoviridae)'. Together they form a unique fingerprint.

    Cite this