Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Xiaoyong Bao; Deepthi Kolli; Dana Esham; Thangam S. Velayutham; Antonella Casola

doi:10.3390/v10060278

Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Xiaoyong Bao, Deepthi Kolli, Dana Esham, Thangam S. Velayutham, Antonella Casola

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.

Original language	English (US)
Article number	278
Journal	Viruses
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/v10060278
State	Published - Jun 1 2018

Fingerprint

Keywords

HMPV
Plasmacytoid dendritic cells
SH protein
Type I IFN

ASJC Scopus subject areas

Infectious Diseases
Virology

Cite this

Bao, X., Kolli, D., Esham, D., Velayutham, T. S., & Casola, A. (2018). Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells. Viruses, 10(6), [278]. https://doi.org/10.3390/v10060278

@article{8c3fedead69745189823bb516d77c240,

title = "Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells",

abstract = "Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.",

keywords = "HMPV, Plasmacytoid dendritic cells, SH protein, Type I IFN",

author = "Xiaoyong Bao and Deepthi Kolli and Dana Esham and Velayutham, {Thangam S.} and Antonella Casola",

year = "2018",

month = jun,

day = "1",

doi = "10.3390/v10060278",

language = "English (US)",

volume = "10",

journal = "Viruses",

issn = "1999-4915",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "6",

}

TY - JOUR

T1 - Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

AU - Bao, Xiaoyong

AU - Kolli, Deepthi

AU - Esham, Dana

AU - Velayutham, Thangam S.

AU - Casola, Antonella

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.

AB - Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.

KW - HMPV

KW - Plasmacytoid dendritic cells

KW - SH protein

KW - Type I IFN

UR - http://www.scopus.com/inward/record.url?scp=85047881055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047881055&partnerID=8YFLogxK

U2 - 10.3390/v10060278

DO - 10.3390/v10060278

M3 - Article

C2 - 29789500

AN - SCOPUS:85047881055

VL - 10

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 6

M1 - 278

ER -

Access to Document

10.3390/v10060278