Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Xiaoyong Bao, Deepthi Kolli, Dana Esham, Thangam S. Velayutham, Antonella Casola

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.

Original languageEnglish (US)
Article number278
JournalViruses
Volume10
Issue number6
DOIs
StatePublished - Jun 1 2018

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Keywords

  • HMPV
  • Plasmacytoid dendritic cells
  • SH protein
  • Type I IFN

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

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