Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Xiaoyong Bao; Deepthi Kolli; Dana Esham; Thangam S. Velayutham; Antonella Casola

doi:10.3390/v10060278

Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Xiaoyong Bao, Deepthi Kolli, Dana Esham, Thangam S. Velayutham, Antonella Casola

Pediatrics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.

Original language	English (US)
Article number	278
Journal	Viruses
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/v10060278
State	Published - Jun 2018

Keywords

HMPV
Plasmacytoid dendritic cells
SH protein
Type I IFN

ASJC Scopus subject areas

Infectious Diseases
Virology

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10.3390/v10060278

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title = "Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells",

abstract = "Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.",

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AU - Bao, Xiaoyong

AU - Kolli, Deepthi

AU - Esham, Dana

AU - Velayutham, Thangam S.

AU - Casola, Antonella

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AB - Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.

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KW - Plasmacytoid dendritic cells

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KW - Type I IFN

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Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Abstract

Keywords

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