@article{8c3fedead69745189823bb516d77c240,
title = "Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells",
abstract = "Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.",
keywords = "HMPV, Plasmacytoid dendritic cells, SH protein, Type I IFN",
author = "Xiaoyong Bao and Deepthi Kolli and Dana Esham and Velayutham, {Thangam S.} and Antonella Casola",
note = "Funding Information: Funding: This work was supported by National Institute of Health grants R01 AI079246, P01 AI062885 and P30 ES006676, MedImmune fellowship (DLE) and James W. McLaughlin Fellowship Fund from UTMB (TSV). Funding Information: This work was supported by National Institute of Health grants R01 AI079246, P01 AI062885 and P30 ES006676, MedImmune fellowship (DLE) and James W. McLaughlin Fellowship Fund from UTMB (TSV). Acknowledgments: The authors are grateful to Cynthia Tribble for her assistance in manuscript editing and submission. Publisher Copyright: {\textcopyright} 2018 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2018",
month = jun,
doi = "10.3390/v10060278",
language = "English (US)",
volume = "10",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}