Abstract
Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.
| Original language | English (US) |
|---|---|
| Article number | 278 |
| Journal | Viruses |
| Volume | 10 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2018 |
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Keywords
- HMPV
- Plasmacytoid dendritic cells
- SH protein
- Type I IFN
ASJC Scopus subject areas
- Infectious Diseases
- Virology
Cite this
Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells. / Bao, Xiaoyong; Kolli, Deepthi; Esham, Dana; Velayutham, Thangam S.; Casola, Antonella.
In: Viruses, Vol. 10, No. 6, 278, 01.06.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells
AU - Bao, Xiaoyong
AU - Kolli, Deepthi
AU - Esham, Dana
AU - Velayutham, Thangam S.
AU - Casola, Antonella
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.
AB - Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.
KW - HMPV
KW - Plasmacytoid dendritic cells
KW - SH protein
KW - Type I IFN
UR - http://www.scopus.com/inward/record.url?scp=85047881055&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047881055&partnerID=8YFLogxK
U2 - 10.3390/v10060278
DO - 10.3390/v10060278
M3 - Article
VL - 10
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 6
M1 - 278
ER -