Human metapneumovirus small hydrophobic protein inhibits interferon induction in plasmacytoid dendritic cells

Xiaoyong Bao, Deepthi Kolli, Dana Esham, Thangam S. Velayutham, Antonella Casola

    Research output: Contribution to journalArticlepeer-review

    9 Scopus citations

    Abstract

    Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-∆SH) enhanced the secretion of type I interferons (IFNs), which required TLR7 and MyD88 expression. HMPV SH protein inhibited TLR7/MyD88/TRAF6 signaling leading to IFN gene transcription, identifying a novel mechanism by which paramyxovirus SH proteins modulate innate immune responses.

    Original languageEnglish (US)
    Article number278
    JournalViruses
    Volume10
    Issue number6
    DOIs
    StatePublished - Jun 2018

    Keywords

    • HMPV
    • Plasmacytoid dendritic cells
    • SH protein
    • Type I IFN

    ASJC Scopus subject areas

    • Infectious Diseases
    • Virology

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