Human metapneumovirus small hydrophobic protein inhibits NF-κB transcriptional activity

Xiaoyong Bao, Deepthi Kolli, Tianshuang Liu, Yichu Shan, Roberto P. Garofalo, Antonella Casola

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Human metapneumovirus, a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. In this study, we showed that infection of airway epithelial cells or mice with recombinant human metapneumovirus lacking SH expression (rhMPV-ΔSH) enhanced secretion of proinflammatory mediators, including interleukin 6 (IL-6) and IL-8, encoded by two NF-kB-dependent genes, compared to infection with wild-type rhMPV. RhMPV-ΔSH infection resulted in enhanced NF-kB-dependent gene transcription and in increased levels of phosphorylated and acetylated NF-kB without affecting its nuclear translocation, identifying a possible novel mechanism by which paramyxovirus SH proteins modulate NF-kB activation.

Original languageEnglish (US)
Pages (from-to)8224-8229
Number of pages6
JournalJournal of virology
Volume82
Issue number16
DOIs
StatePublished - Aug 2008

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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