Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Chad Mire, Robert Cross, Joan B. Geisbert, Viktoriya Borisevich, Krystle N. Agans, Daniel J. Deer, Megan L. Heinrich, Megan M. Rowland, Augustine Goba, Mambu Momoh, Mathew L. Boisen, Donald S. Grant, Mohamed Fullah, Sheik Humarr Khan, Karla A. Fenton, James E. Robinson, Luis M. Branco, Robert F. Garry, Thomas Geisbert

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.

Original languageEnglish (US)
Pages (from-to)1146-1149
Number of pages4
JournalNature Medicine
Volume23
Issue number10
DOIs
StatePublished - Oct 1 2017

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Lassa Fever
Lassa virus
Western Africa
Macaca
Viruses
Primates
Glycoproteins
Monoclonal Antibodies
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever. / Mire, Chad; Cross, Robert; Geisbert, Joan B.; Borisevich, Viktoriya; Agans, Krystle N.; Deer, Daniel J.; Heinrich, Megan L.; Rowland, Megan M.; Goba, Augustine; Momoh, Mambu; Boisen, Mathew L.; Grant, Donald S.; Fullah, Mohamed; Khan, Sheik Humarr; Fenton, Karla A.; Robinson, James E.; Branco, Luis M.; Garry, Robert F.; Geisbert, Thomas.

In: Nature Medicine, Vol. 23, No. 10, 01.10.2017, p. 1146-1149.

Research output: Contribution to journalArticle

Mire, C, Cross, R, Geisbert, JB, Borisevich, V, Agans, KN, Deer, DJ, Heinrich, ML, Rowland, MM, Goba, A, Momoh, M, Boisen, ML, Grant, DS, Fullah, M, Khan, SH, Fenton, KA, Robinson, JE, Branco, LM, Garry, RF & Geisbert, T 2017, 'Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever', Nature Medicine, vol. 23, no. 10, pp. 1146-1149. https://doi.org/10.1038/nm.4396
Mire, Chad ; Cross, Robert ; Geisbert, Joan B. ; Borisevich, Viktoriya ; Agans, Krystle N. ; Deer, Daniel J. ; Heinrich, Megan L. ; Rowland, Megan M. ; Goba, Augustine ; Momoh, Mambu ; Boisen, Mathew L. ; Grant, Donald S. ; Fullah, Mohamed ; Khan, Sheik Humarr ; Fenton, Karla A. ; Robinson, James E. ; Branco, Luis M. ; Garry, Robert F. ; Geisbert, Thomas. / Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever. In: Nature Medicine. 2017 ; Vol. 23, No. 10. pp. 1146-1149.
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