Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Chad E. Mire; Robert W. Cross; Joan B. Geisbert; Viktoriya Borisevich; Krystle N. Agans; Daniel J. Deer; Megan L. Heinrich; Megan M. Rowland; Augustine Goba; Mambu Momoh; Mathew L. Boisen; Donald S. Grant; Mohamed Fullah; Sheik Humarr Khan; Karla A. Fenton; James E. Robinson; Luis M. Branco; Robert F. Garry; Thomas W. Geisbert

doi:10.1038/nm.4396

Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Chad E. Mire
, Robert W. Cross
, Joan B. Geisbert
, Viktoriya Borisevich
, Krystle N. Agans
, Daniel J. Deer
, Megan L. Heinrich
, Megan M. Rowland
, Augustine Goba
, Mambu Momoh
, Mathew L. Boisen
, Donald S. Grant
, Mohamed Fullah
, Sheik Humarr Khan
, Karla A. Fenton
, James E. Robinson
, Luis M. Branco
, Robert F. Garry
, Thomas W. Geisbert

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

110 Scopus citations

Abstract

There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.

Original language	English (US)
Pages (from-to)	1146-1149
Number of pages	4
Journal	Nature Medicine
Volume	23
Issue number	10
DOIs	https://doi.org/10.1038/nm.4396
State	Published - Oct 1 2017

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1038/nm.4396

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Mire, C. E., Cross, R. W., Geisbert, J. B., Borisevich, V., Agans, K. N., Deer, D. J., Heinrich, M. L., Rowland, M. M., Goba, A., Momoh, M., Boisen, M. L., Grant, D. S., Fullah, M., Khan, S. H., Fenton, K. A., Robinson, J. E., Branco, L. M., Garry, R. F., & Geisbert, T. W. (2017). Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever. Nature Medicine, 23(10), 1146-1149. https://doi.org/10.1038/nm.4396

Mire, CE, Cross, RW, Geisbert, JB, Borisevich, V, Agans, KN, Deer, DJ, Heinrich, ML, Rowland, MM, Goba, A, Momoh, M, Boisen, ML, Grant, DS, Fullah, M, Khan, SH, Fenton, KA, Robinson, JE, Branco, LM, Garry, RF & Geisbert, TW 2017, 'Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever', Nature Medicine, vol. 23, no. 10, pp. 1146-1149. https://doi.org/10.1038/nm.4396

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Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Abstract

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