Human monocytic and granulocytic ehrlichioses: Discovery and diagnosis of emerging tick, borne infections and the critical role of the pathologist

David H. Walker, J. Stephen Dumler

Research output: Contribution to journalReview article

98 Scopus citations


Human monocytic ehrlichiosis and human granulocytic ehrlichiosis are emerging tick-borne infections in the United States. The clinical presentations of these two distinct, potentially life-threatening infections are fever, headache, myalgia, and other diagnostically nonspecific symptoms. Physician awareness is lacking and appropriate diagnostic tests are still not widely available. Because few documented cases have been autopsied, the pathology of human monocytic ehrlichiosis and human granulocytic ehrlichiosis is incompletely described. In human monocytic ehrlichiosis, bone marrow and hepatic granulomas and multiorgan perivascular lymphohistiocytic infiltrates have been observed. In human granulocytic ehrlichiosis, opportunistic fungal and vital infections have been important findings. To expedite an analysis of the pathology and pathogenesis of the human ehrlichioses, it is proposed that a Registry of Pathology of Human Ehrlichioses be established.

Original languageEnglish (US)
Pages (from-to)785-791
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Issue number8
StatePublished - Sep 6 1997


ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this