Human Monocytotropic Ehrlichiosis, Missouri

Juan Olano, Edwin Masters, Wayne Hogrefe, David Walker

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

To determine the incidence, clinical and laboratory characteristics, and utility of molecular diagnosis of human monocytotropic ehrlichiosis (HME) in the primary care setting, we conducted a prospective study in an outpatient primary care clinic in Cape Girardeau, Missouri. One hundred and two patients with a history of fever for 3 days (>37.7°C), tick bite or exposure, and no other infectious disease diagnosis were enrolled between March 1997 and December 1999. HME was diagnosed in 29 patients by indirect immunofluorescent antibody assay and polymerase chain reaction (PCR). Clinical and laboratory manifestations included fever (100%), headache (72%), myalgia or arthralgia (69%), chills (45%), weakness (38%), nausea (38%), leukopenia (60%), thrombocytopenia (56%), and elevated aspartate aminotransferase level (52%). Hospitalization occurred in 41% of case-patients. PCR sensitivity was 56%; specificity, 100%. HME is a prevalent, potentially severe disease in southeastern Missouri that often requires hospitalization. Because clinical presentation of HME is nonspecific, PCR is useful in the diagnosis of acute HME.

Original languageEnglish (US)
Pages (from-to)1579-1586
Number of pages8
JournalEmerging Infectious Diseases
Volume9
Issue number12
StatePublished - Dec 2003

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Ehrlichiosis
Polymerase Chain Reaction
Primary Health Care
Hospitalization
Fever
Tick Bites
Chills
Myalgia
Leukopenia
Arthralgia
Ambulatory Care
Aspartate Aminotransferases
Thrombocytopenia
Nausea
Communicable Diseases
Headache
Prospective Studies
Antibodies
Incidence

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Human Monocytotropic Ehrlichiosis, Missouri. / Olano, Juan; Masters, Edwin; Hogrefe, Wayne; Walker, David.

In: Emerging Infectious Diseases, Vol. 9, No. 12, 12.2003, p. 1579-1586.

Research output: Contribution to journalArticle

Olano, J, Masters, E, Hogrefe, W & Walker, D 2003, 'Human Monocytotropic Ehrlichiosis, Missouri', Emerging Infectious Diseases, vol. 9, no. 12, pp. 1579-1586.
Olano, Juan ; Masters, Edwin ; Hogrefe, Wayne ; Walker, David. / Human Monocytotropic Ehrlichiosis, Missouri. In: Emerging Infectious Diseases. 2003 ; Vol. 9, No. 12. pp. 1579-1586.
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